Abstract: FR-PO0739
CKD Progression in Children with Treated Controlled Hypertension Compared with CKD Progression in Normotensive Peers
Session Information
- Pediatric Nephrology: CKD, ESKD, and Glomerular Diseases
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Pediatric Nephrology
- 1900 Pediatric Nephrology
Authors
- Roem, Jennifer, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States
- Samuels, Joshua A., The University of Texas Health Science Center at Houston John P and Katherine G McGovern Medical School, Houston, Texas, United States
- Warady, Bradley A., Children's Mercy Kansas City, Kansas City, Missouri, United States
- Furth, Susan L., The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
- Ng, Derek K., Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States
- Mitsnefes, Mark, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
Group or Team Name
- CKiD Study Investigators.
Background
Treating hypertension is a crucial component of pediatric CKD management, but it is not known whether CKD progression risk is higher among children with controlled treated hypertension compared to those who never were diagnosed with hypertension and free of therapy.
Methods
Data were derived from the Chronic Kidney Disease in Children (CKiD) cohort and was restricted to those participants with normal BP stratified into two groups. The exposed group consisted of participants with two consecutive annual visits with diagnosis of hypertension and antihypertensive therapy use who were matched to a reference group that consisted of children with no diagnosis of hypertension and no reported antihypertensive therapy use. Matching was based on sex, age, CKD diagnosis, eGFR, and uPCr, and we quantified differences in eGFR trajectory (linear mixed model) and time to kidney replacement therapy (KRT; Cox proportional hazards model).
Results
A total of 219 children with persistent controlled BP were matched to 219 controls with normal BP. The observed eGFR levels of the two groups were similar at baseline (50 vs 49; p=0.86), as were changes in eGFR over time (-4% vs -5%; p=0.16). The relative hazard of time to KRT was not significantly different between those with controlled hypertension (HR: 1.3; 95%CI: 0.8, 2.1) compared to those participants without a diagnosis of hypertension and no reported antihypertensive medication use.
Conclusion
Participants with controlled hypertension had similar CKD progression as those who never had a diagnosis of hypertension after matching for sex, age, CKD diagnosis, eGFR, and uPCr. These data support the importance of early diagnosis and effective therapy for children with hypertension and CKD.
Survival time to kidney replacement therapy (KRT) stratified by controlled BP and matched normal BP.
Funding
- NIDDK Support