Kidney Week

Abstract: FR-PO1129

Factors Associated with Variability in Home-Based Kidney Function Measures

Session Information

• CKD: Screening, Diagnosis, Serum and Urine Biomarkers, and Scoring Indices
  November 07, 2025 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Larkin, Claire T., University of Illinois Chicago, Chicago, Illinois, United States

Claire T. Larkin, MD, MPH

• Appel, Lawrence J., Johns Hopkins Medicine, Baltimore, Maryland, United States

Lawrence J. Appel, MD, MPH

• Chen, Jing, The University of Texas Southwestern Medical Center, Dallas, Texas, United States

Jing Chen, MD, MS, MSc, FASN

• Cohen, Debbie L., University of Pennsylvania, Philadelphia, Pennsylvania, United States

Debbie L. Cohen, MD, FASN

• Dember, Laura M., University of Pennsylvania, Philadelphia, Pennsylvania, United States

Laura M. Dember, MD, FASN

• Hsu, Jesse Yenchih, University of Pennsylvania, Philadelphia, Pennsylvania, United States

Jesse Yenchih Hsu, PhD

• Hsu, Chi-yuan, University of California San Francisco, San Francisco, California, United States

Chi-yuan Hsu, MD, MS, MSc, FASN

• Parsa, Afshin, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, United States

Afshin Parsa, MD, MPH, FASN

• Rahman, Mahboob, Case Western Reserve University, Cleveland, Ohio, United States

Mahboob Rahman, MD, MBBS

• Shah, Vallabh O., The University of New Mexico, Albuquerque, New Mexico, United States

Vallabh O. Shah, MS, PhD, FASN

• Unruh, Mark L., The University of New Mexico, Albuquerque, New Mexico, United States

Mark L. Unruh, MD, MS

• Rao, Panduranga S., University of Michigan, Ann Arbor, Michigan, United States

Panduranga S. Rao, MD, MBBS, MS

• Go, Alan S., The Permanente Medical Group Inc, Oakland, California, United States

Alan S. Go, MD

• Lash, James P., University of Illinois Chicago, Chicago, Illinois, United States

James P. Lash, MD, FASN

Background

Evidence suggests that kidney function variability may be associated with adverse outcomes. Between 2019-2024, 1,034 Chronic Renal Insufficiency Cohort participants completed a monthly home-based kidney function protocol consisting of fingerstick whole blood creatinine (NovaMax creatinine analyzer) and albuminuria (urine dipstick and smartphone app). The aim of this study is to identify factors associated with variability of home-based kidney function measures.

Methods

We analyzed individuals with ≥6 measures of fingerstick blood creatinine (n=847) and ≥6 albuminuria measures (n=830) during the 12-month period. Creatinine variability was defined as SD/mean; variability of albuminuria (a categorical variable) assessed using Shannon's entropy. Multivariable logistic regression evaluated the association of baseline factors with highest vs lowest variability quartile.

Results

At baseline, mean age 68 years, 47% White, 32% Black, 17% Hispanic, 53% had diabetes, 31% had CVD, mean eGFR 52.5 ml/min/1.73m², and median protein-to-creatine ratio 0.2. Baseline fingerstick creatinine was highly correlated with the simultaneously drawn serum creatinine (Figure a). Figures b and c show distributions of fingerstick creatinine and albuminuria variability. Multivariable predictors are listed in the Table.

Conclusion

Select demographic and clinical factors were associated with variability of home-based creatinine and albuminuria. Future work is needed to assess the association of kidney function variability with long term outcomes.

Funding

• NIDDK Support

Digital Object Identifier (DOI)

• doi: 10.1681/ASN.2025wkjgjqn0