Abstract: FR-OR006
CRRT Utilization Trends and Economic Impact in AKI Patients Requiring Renal Replacement Therapy: A Nationwide Analysis
Session Information
- AKI Everywhere All at Once: Risks, Trajectories, and Practice Patterns
November 07, 2025 | Location: Room 320A, Convention Center
Abstract Time: 05:20 PM - 05:30 PM
Category: Acute Kidney Injury
- 101 AKI: Epidemiology, Risk Factors, and Prevention
Authors
- Bizer, Benjamin, Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Thongprayoon, Charat, Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Kaewput, Wisit, Phramongkutklao College of Medicine, Bangkok, Thailand
- Suppadungsuk, Supawadee, Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Kashani, Kianoush, Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Cheungpasitporn, Wisit, Mayo Clinic Minnesota, Rochester, Minnesota, United States
Background
Continuous Renal Replacement Therapy (CRRT) is increasingly utilized in the management of Acute Kidney Injury (AKI) patients requiring RRT. This study examines trends in CRRT use, in-hospital mortality, and hospitalization costs over a four-year period using the National Inpatient Sample (NIS) HCUP database.
Methods
A retrospective cohort study was conducted on 217,708 AKI cases requiring RRT from 2018 to 2021. CRRT utilization, in-hospital mortality, and hospitalization costs were analyzed across calendar years using linear regression to assess trend significance (p-trend). Multivariable logistic regression models adjusted for demographics, hospital characteristics, and clinical variables were employed. Data were obtained from the NIS, a nationally representative database of U.S. hospital discharges.
Results
CRRT utilization increased significantly from 17.13% in 2018 to 32.73% in 2021 (p-trend < 0.001). Despite the increased CRRT use, the in-hospital mortality rate remained consistently high across all years, averaging 59.33% (p-trend = 0.134). Median hospitalization costs for CRRT patients showed a substantial increase from $144,672 in 2018 to $280,180 in 2021 (p-trend < 0.001). Notable predictors of CRRT use included younger age, male gender, and higher Charlson Comorbidity Index scores.
Conclusion
The use of CRRT in AKI patients requiring RRT has significantly increased over time, while in-hospital mortality has remained persistently high. The associated costs of hospitalization for CRRT patients have also escalated substantially, underscoring the need for targeted interventions to mitigate adverse outcomes and optimize cost-effective care in this high-risk population.