Abstract: FR-PO1072
Multicenter Randomized Controlled Study of the Efficacy of Low-Protein Rice for Dietary Protein Restriction in Patients with CKD
Session Information
- Health Maintenance, Nutrition, and Metabolism
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Hosojima, Michihiro, Department of Clinical Nutrition Science, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
- Kabasawa, Hideyuki, Department of Clinical Nutrition Science, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
- Tanaka, Mai, Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
- Murayama, Toshiko, Department of Health and Nutrition, Faculty of Human Life Studies, University of Niigata Prefecture, Niigata, Japan
- Goto, Shin, Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
- Narita, Ichiei, Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
- Saito, Akihiko, Department of Applied Molecular Medicine, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
- Yamamoto, Suguru, Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Background
The efficacy and safety of low-protein diets (LPDs) in patients with chronic kidney disease (CKD) remain unclear. Rice, a major staple food worldwide, is the primary source of dietary proteins, especially in Asia. Therefore, a long-term prospective study including a methodology involving the use of low-protein rice (LPR) is required.
Methods
Between September 2019 and March 2024, a multicenter, randomized controlled trial was conducted involving 112 CKD patients (mean age: 63.1±10.8 years) with stage G3aA2 to G4, receiving outpatient care at Niigata University and seven affiliated hospitals. Participants were randomly assigned to either a control group receiving only nutritional guidance (no LPR group) to meet the nutritional goal (dietary protein restriction [0.7 g/kg ideal body weight/day]) or an intervention group receiving nutritional guidance and LPR (at least twice daily; LPR group) for 120 weeks. This study aimed to compare the impact on renal function over time and assess its usefulness in adherence to the LPD (Trial Registration Number: jRCTs031190063).
Results
The two groups showed no significant difference in renal function change, as measured by creatinine clearance (Ccr, ml/min), from baseline to 120 weeks (LPR group: -8.811 [95% CI: -11.649, -5.973]; no LPR group: -6.284 [-9.218, -3.351]). Renal prognosis between the groups also revealed no significant differences, as defined by events such as the initiation of renal replacement therapy or a 50% reduction in Ccr. Throughout the study period, the LPR group had significantly lower protein intake and higher energy intake. The two groups showed no significant difference in skeletal muscle mass change, as assessed by segmental multiple-frequency bioelectric impedance measurements. No specific complications were associated with the use of LPR during the intervention period.
Conclusion
This study did not demonstrate a significant effect of the LPD using LPR on slowing the decline in renal function among patients with CKD. Further research is needed to clarify the impact of LPDs on the progression of renal dysfunction. Nonetheless, LPR appears to be a useful tool for facilitating adherence to the LPD.
Funding
- Commercial Support – Biotech Japan Corporation, Forica Foods Co., Ltd., Kameda Seika Co., Ltd., and Sato Foods Co., Ltd.