Abstract: TH-PO1076
Disparities Due to Pneumonia-Related Deaths in Patients with CKD: A Centers for Disease Control (CDC) Wonder Analysis, 1999-2020
Session Information
- CKD: Epidemiology, Risk Factors, and Other Conditions
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Ali, Muhammad, Dow International Medical College, Karachi, Sindh, Pakistan
- Memon, Zauha Fawad, Peoples University of Medical and Health Sciences for Women, Nawabshah, Sindh, Pakistan
- Memon, Sibgha Fawad, Peoples University of Medical and Health Sciences for Women, Nawabshah, Sindh, Pakistan
- Memon, Matia Fawad, Peoples University of Medical and Health Sciences for Women, Nawabshah, Sindh, Pakistan
Background
Pneumonia is a major cause of death among chronic kidney disease (CKD) patients, with a mortality rate 14-16 fold higher than the general population. Increased risk of pneumonia-related mortality in CKD patients is linked to decreased immunity and higher rate of comorbidities. This study explores pneumonia-related mortality in CKD to inform prevention and care strategies.
Methods
We conducted a retrospective population-based study using the Centers for Disease Control and Prevention's (CDC WONDER) death certificate data (1999-2020). Subjects with Chronic Kidney Disease (CKD) and Pneumonia were selected. Age-adjusted mortality rates (AAMR) per 100,000 were calculated, and trends were assessed using Joinpoint regression to estimate annual and average annual percent change (APC, AAPC). Rates were stratified by year, gender, race, region, and urbanization.
Results
136,723 pneumonia-related deaths in CKD patients occurred from 1999 to 2020, mostly in men (men: 56.25%, women: 43.75%). Overall, AAMR increased from 2.59 in 1999 to 5.05 in 2020 (AAPC: 1.45%, 95% CI: -0.12 to 3.06), with men displaying higher AAMR versus women (4.03 vs 2.14). Racially, Black /African Americans had the highest AAMR (10.29 in 2020) (AAPC: 2.00, p < 0.225495). American Indian /Alaska Natives had a notable spike in AAMR of 7.65 in 2011 and 9.82 in 2020, whereas trends in Asian or Pacific Islanders (AAPC: -0.87, p < 0.267691) and Whites (AAPC: 1.16, p < 0.093619) remained stable. Hispanic /Latinos had unremarkable AAMR trends aside from a spike to 7.48 in 2020. Regionally, the South had the highest deaths (50,028). All U.S. Census regions showed statistically significant increases in AAMR, with the South (AAPC: 3.00) and Northeast (AAPC: 2.20) regions leading the way. Urban and rural areas saw a substantial rise, though more pronounced in rural (AAPC: 2.16, p < 0.005825) compared to urban areas (AAPC: 1.13, p < 0.106143).
Conclusion
Over the last 2 decades, pneumonia-related mortality in CKD patients has remarkably increased, especially in men, Black populations, the South, and rural areas. These findings highlight the need for targeted public health interventions and equitable access to address these disparities.