Kidney Week

Abstract: SA-PO1176

Effect of Transcatheter Edge-to-Edge Repair on Kidney Function in Patients with Severe Tricuspid Regurgitation

Session Information

• CKD: SGLT2 Inhibitors and GLP-1 RAs for Kidney Health
  November 08, 2025 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2302 CKD (Non-Dialysis): Clinical, Outcomes, and Trials

Authors

• Becker, Mathias, Robert-Bosch-Krankenhaus GmbH, Stuttgart, BW, Germany

Mathias Becker, MD

• Kraft, Leonie, Robert-Bosch-Krankenhaus GmbH, Stuttgart, BW, Germany

Leonie Kraft, MD, DrMed

• Oberacker, Tina, Doktor Margarete Fischer-Bosch-Institut fur Klinische Pharmakologie, Stuttgart, BW, Germany

Tina Oberacker

• Schricker, Severin, Robert-Bosch-Krankenhaus GmbH, Stuttgart, BW, Germany

Severin Schricker, MD, DrMed

• Schwab, Andrea, Robert-Bosch-Krankenhaus GmbH, Stuttgart, BW, Germany

Andrea Schwab

• Biegger, Dagmar, Doktor Margarete Fischer-Bosch-Institut fur Klinische Pharmakologie, Stuttgart, BW, Germany

Dagmar Biegger

• Eker-Dayi, Betül, Robert-Bosch-Krankenhaus GmbH, Stuttgart, BW, Germany

Betül Eker-Dayi, MD

• Kettler, Lisa, Robert-Bosch-Krankenhaus GmbH, Stuttgart, BW, Germany

Lisa Kettler, MD

• Moussaoui, Zineb, Robert-Bosch-Krankenhaus GmbH, Stuttgart, BW, Germany

Zineb Moussaoui, MD

• Schönfelder, Monika, Robert-Bosch-Krankenhaus GmbH, Stuttgart, BW, Germany

Monika Schönfelder, MD

• Leonhardt, Rebekka, Robert-Bosch-Krankenhaus GmbH, Stuttgart, BW, Germany

Rebekka Leonhardt, MD

• Riegger, Lukas, Robert-Bosch-Krankenhaus GmbH, Stuttgart, BW, Germany

Lukas Riegger, MD

• Grau, Julian, Robert-Bosch-Krankenhaus GmbH, Stuttgart, BW, Germany

Julian Grau, MD

• Müller-Kühnle, Julian, Robert-Bosch-Krankenhaus GmbH, Stuttgart, BW, Germany

Julian Müller-Kühnle, MD, PhD

• Klenk, Jochen, Robert-Bosch-Krankenhaus GmbH, Stuttgart, BW, Germany

Jochen Klenk, PhD

• Nikolai, Philipp, Robert-Bosch-Krankenhaus GmbH, Stuttgart, BW, Germany

Philipp Nikolai, MD

• Rapp, Kilian, Robert-Bosch-Krankenhaus GmbH, Stuttgart, BW, Germany

Kilian Rapp, MD

• Bekeredjian, Raffi, Robert-Bosch-Krankenhaus GmbH, Stuttgart, BW, Germany

Raffi Bekeredjian, MD

• Latus, Joerg, Robert-Bosch-Krankenhaus GmbH, Stuttgart, BW, Germany

Joerg Latus, MD

• Schanz, Moritz, Robert-Bosch-Krankenhaus GmbH, Stuttgart, BW, Germany

Moritz Schanz, DrMed, MBA

Background

Severe tricuspid regurgitation (TR) can lead to significant organ dysfunction, including renal impairment. However, data on the impact of TR on kidney function and outcomes after interventional treatment remain scarce. This study aims to investigate the initial renal function of patients with high-grade tricuspid valve insufficiency undergoing interventional Transcatheter edge-to-edge repair (T-TEER) procedure and the course of kidney function after intervention.

Methods

This retrospective, observational single-center study included n=181 consecutive patients with severe, massive and torrential TR who underwent T-TEER implantation conducted at Robert Bosch Hospital Stuttgart (Germany) between March 2021 and February 2023, with median follow-up of 125 days (IQR 6-506) up to 1280 days. Follow up included all routine records in our EHRs. Cases with insufficient data were excluded.

Results

Among the 181 patients analyzed, baseline renal function showed a median estimated glomerular filtration rate (eGFR, CKD-EPI) of 53 mL/min/1.73m² [41-65]. Chronic kidney disease (CKD) was present in more than two thirds (64%) of patients, with 30% classified as CKD stage G3a, 26% as G3b, 8% as G4, and 5% were on dialysis (n=9).
Renal function, as measured by eGFR, improved from 52.7 ± 17.3ml/min/1.73m² to 59.5 ± 18.8ml/min/1.73m² (p < 0.0001), and eGFR-slopes were significantly less steep (p < 0.0001) (Figure 1). Cumulative hazard of AKI events were less frequent in lower CKD-Stages.

Conclusion

Our data indicate that the CKD prevalence in patients with high-grade TR is remarkably high, and the findings suggest that renal function improve over time in patients following intervention. These observations highlight the need for further prospective studies to systematically evaluate renal function outcomes after T-TEER.

eGFR slope before and after T-TEER

Funding

• Private Foundation Support

Digital Object Identifier (DOI)

• doi: 10.1681/ASN.2025vm92z7x1