Abstract: FR-PO0513
Dialysis Adequacy on Tablo Hemodialysis Machines Related to Patient Weight
Session Information
- Dialysis: Hemodiafiltration, Ultrafiltration, Profiling, and Interdialytic Symptoms
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Jacob, Shancy, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States
- Badalamenti, John, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States
- Brown, Tammy R, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States
- Monga, Divya, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States
- Rawala, Muhammad, The University of Texas Medical Branch at Galveston, Galveston, Texas, United States
- Israni, Ajay K., The University of Texas Medical Branch at Galveston, Galveston, Texas, United States
Background
Tablo Hemodialysis (HD) machines are newer machines with maximum dialysate flow rate of 300ml/min. Therefore we conducted an IRB approved study to evaluate whether adequate dialysis clearance is obtained with the dialysate flow rate of 300ml/min.
Methods
Hemodynamically stable end stage renal disease patients with age over 18 years receiving routine dialysis during hospitalization were included. Patients with acute kidney injury or hemodynamic instability were excluded. Serum blood urea nitrogen lab was drawn at the beginning and end of dialysis and this was performed once for each patient. Based on the urea reduction ratio (URR), the treating provider would change the patient’s dialysis prescription for future adequacy. Primary outcome was to reach URR > 65% and spKt/v >1.2.
Results
Patients that weighed less than 80kg had a mean URR > 65% and spKt/V> 1.2 and were able to achieve primary outcome (figure 1). However, patients that weighed more than 80kg were unable to reach primary outcome. Then a larger dialyzer, Optiflux F250NR, was used on patients that weighed more than 80kg and 9 out of the 12 patients were able to achieve adequate clearance (figure 2).
Conclusion
Tablo HD machine has reduced clearance with higher patient weights. Larger dialyzers, increased time or frequency of dialysis should be considered. Limitations include that the 12 treatments with Optiflux F250NR wasn't enough for statistical significance but most patients achieved clearance.