Abstract: SA-PO0228
Kidney and Nutritional Outcomes of a Mediterranean Controlled Protein Diet in Onconephrological Patients
Session Information
- Onconephrology: MGRS, HSCT, Electrolytes, RCC, and More
November 08, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Onconephrology
- 1700 Onconephrology
Authors
- Trevisani, Francesco, IRCCS Ospedale San Raffaele, Milan, Lombardy, Italy
- Monti, Agnese, IRCCS Ospedale San Raffaele, Milan, Lombardy, Italy
- Angioi, Andrea, Azienda Ospedaliera Brotzu, Cagliari, Sardinia, Italy
- Floris, Matteo, Azienda Ospedaliera Brotzu, Cagliari, Sardinia, Italy
- Fiorio, Francesco, IRCCS Ospedale San Raffaele, Milan, Lombardy, Italy
- Selvaggi, Fabiana, IRCCS Ospedale San Raffaele, Milan, Lombardy, Italy
- Passera, Michela, IRCCS Ospedale San Raffaele, Milan, Lombardy, Italy
- Briganti, Alberto, IRCCS Ospedale San Raffaele, Milan, Lombardy, Italy
- Salonia, Andrea, IRCCS Ospedale San Raffaele, Milan, Lombardy, Italy
- Montorsi, Francesco, IRCCS Ospedale San Raffaele, Milan, Lombardy, Italy
- Pani, Antonello, Azienda Ospedaliera Brotzu, Cagliari, Sardinia, Italy
- Rosiello, Giuseppe, IRCCS Ospedale San Raffaele, Milan, Lombardy, Italy
- Capitanio, Umberto, IRCCS Ospedale San Raffaele, Milan, Lombardy, Italy
- Bettiga, Arianna, IRCCS Ospedale San Raffaele, Milan, Lombardy, Italy
Background
Onconephrological patients often face the dual burden of chronic kidney disease (CKD) and cancer-related metabolic derangements. Despite existing nutritional strategies for each condition individually, integrated dietary approaches remain underexplored. This study aimed to evaluate the impact of a Mediterranean-like controlled protein diet (MCPD) on renal and nutritional parameters in a cohort of uro-oncological patients.
Methods
A retrospective cohort of 183 adult patients (83.1% male; median age 69.0 years) with CKD and a history of urological malignancy was enrolled. Renal function (creatinine, cystatin C, eGFR) and nutritional status were assessed using bioelectrical impedance analysis (BIA), anthropometry, and clinical history. Seven longitudinal evaluations were performed. Key BIA parameters included BCM%, FM%, FFM%, TBW%, ECW/ICW, and ECM/BCM; anthropometric indices included BMI, body circumferences, and skinfold thickness. Statistical analysis was performed using Wilcoxon signed-rank tests.
Results
At follow-up, serum urea levels significantly decreased (p=0.001), while no significant changes were found in creatinine, cystatin C, or eGFR. BIA showed significant improvements in BCM% (p=0.02), FFM% (p=0.05), TBW% (p=0.03), and reductions in FM% (p=0.03) and ECW/ICW (p=0.04). Among anthropometric measures, hip (p=0.01) and arm circumferences (p=0.007) significantly decreased. Other parameters, including body weight, BMI, SMI, and phase angle, remained stable.
Conclusion
This study supports the use of a tailored MCPD as an effective nutritional intervention capable of preserving renal stability while promoting improvements in body composition and fluid distribution in onconephrological patients. To date, no specific guidelines exist for the nutritional management of patients with both CKD and cancer. In this context, MCPD represents an essential tool to prevent CKD progression during oncological treatments and to counteract malnutrition.