Abstract: TH-PO0462
Multisystemic Predictors of Carotid Intima-Media Thickness in Patients on Hemodialysis: Vascular Echo of Inflammation, Mineral Imbalance, and Thyroid Dysfunction
Session Information
- Hemodialysis: Novel Markers and Case Reports
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Jimenez Hernandez, Mario, Hospital Universitario, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico
- Sosa Rocha, Geovani, Hospital Universitario, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico
- Paniagua, Paulina, Universidad de las Americas Puebla Escuela de Ciencias, Cholula, Mexico
- Rosas, Mari Carmen, Hospital Universitario, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico
- Bello, Marco Esteban, Universidad de las Americas Puebla Escuela de Ciencias, Cholula, Mexico
- Rosales Stevenson, Ivana Aranza, Universidad de las Americas Puebla Escuela de Ciencias, Cholula, Mexico
- Maréchal, Arunka T, Universidad de las Americas Puebla Escuela de Ciencias, Cholula, Mexico
- Castillo García, Armando, Universidad de las Americas Puebla Escuela de Ciencias, Cholula, Mexico
Background
Carotid intima-media thickness (CIMT) reflects subclinical atherosclerosis and arterial remodeling in chronic kidney disease. While inflammation and mineral bone disorder are established contributors, the role of thyroid dysfunction and other systemic factors remains underexplored in dialysis populations.
Objective:
To evaluate the association of CIMT with inflammatory, mineral, hematologic, and endocrine markers in hemodialysis patients, aiming to uncover novel predictive pathways of vascular remodeling.
Methods
We conducted a multicenter cross-sectional study in chronic hemodialysis patients, analyzing CIMT via carotid duplex ultrasound and assessing serum levels of inflammatory (CRP, leukocytes), mineral (PTH, phosphatase), metabolic (HbA1c, lipids), hematologic (hemoglobin), and thyroid (TSH, T4) markers. Correlation and multivariable linear regression analyses were performed. ANOVA tested CIMT differences by categorized biomarker levels.
Results
Among 131 patients (mean age 61±8 years), CIMT correlated positively with CRP (r = 0.42), leukocyte count (r = 0.55), TSH (r = 0.71), and T4 (r = 0.39), while it was inversely associated with PTH (r = –0.38), hemoglobin (r = –0.21), and phosphatase levels (r = –0.29). Multivariate regression confirmed CRP and TSH as independent predictors of CIMT. ANOVA showed significant CIMT differences across inflammatory and PTH strata (p < 0.05).
Conclusion
Our findings highlight a multisystemic interplay—combining inflammation, endocrine imbalance, and anemia—in the progression of vascular damage in dialysis patients. CIMT may serve as an integrative vascular biomarker, reinforcing the need for a holistic, cross-disciplinary approach to cardiovascular risk in this population