Abstract: FR-PO0487
Interdialysis Blood Pressure Increase: Unexplored Relationships
Session Information
- Dialysis: Hemodiafiltration, Ultrafiltration, Profiling, and Interdialytic Symptoms
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Diaz Cabral, Adolfo, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, CDMX, Mexico
- Delgado Avila, Brenda Guadalupe, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, CDMX, Mexico
- Argaiz, Eduardo R., Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, CDMX, Mexico
- Vega, Olynka, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, CDMX, Mexico
- Correa-Rotter, Ricardo, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, CDMX, Mexico
- Rodriguez-Iturbe, Bernardo, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, CDMX, Mexico
Background
Dry weight increases due to water retention are associated to higher blood pressure (BP) and adverse cardiovascular effects in HD patients. However, weight changes between a dialysis session and the next one, do not have a predictable relation with the interdialytic BP changes. Inconsistencies may be due in part to unreliability of clinic BP measurements but factors other than fluid overload may also play a determinant role. We examined the association of interdialytic weight gain (IDWG) with serum angiotensin II (AngII), norepinephrine (NE), copeptin and inflammatory markers levels with the changes in clinic BP and mean interdialytic ambulatory blood pressure measurements (ABPM).
Methods
We studied 30 patients on regular and stable HD thrice weekly. Ultrafiltration was prescribed during HD, in order to reach the clinically estimated dry weight. ABPM was monitored during 23-44 hours in the interdialytic period. Predialysis serum samples were used for laboratory determinations. Three groups were defined according to ABPM.
Results
Table 1
Conclusion
AngII levels play an important role in hypertension of HD patients (correlation between ABPM and AngII levels r=0.42; 95% CI 0.07 to 0.70; p=0.02). There was no correlation between IDWG and AngII levels. Interdialysis blood pressure changes and mean interdialysis ambulatory blood pressure were unrelated to IDWG.
Results. Table 1.
| ABPM | ||||
| Markers | A.<130(n=14) | A.130-139 (n=8) | A.≥140 (n=8) | p |
| Interdialysis clinic SBP change (mmHg) | 10.5±4.49(0.8 to 20.2) | -4.1±6.36*(-19.6 to 10.9) | 23.9±10.02*(0.2 to 47.6) | *(B vs C)0.03 |
| IDWG (% of dry weight, kg) | 2.85±0.38(2.0 to 3.7) | 3.43±0.66(1.86 to 4.98) | 2.56±0.52(1.34 to 3.79) | 0.533 |
| Ang II (pg/ml) | 106.9±12.4&(80.1 to 133.6) | 178.0±35.5(94.1 to 262) | 273.5±39.9&(129.2 to 317.9) | &(A vs C)0.011 |
| Norepinephrine (pg/min) | 117.4±31.4(49.7 – 185.2) | 146.1±51.6(24.1 to 268) | 140.5±52.2(17.1 to 263.9) | 0.867 |
| Copeptin (pg/ml) | 155.2±9.8 (n=11)(133.6 to 176.6) | 115.2±12.0 (n=7)(85.8 to 144.5) | 154.2±20.3 (n=7)(104.6 to 203.9) | 0.10 |
| TNFα (pg/ml) | 20.7±6.36 (n=12)(6.70 to 34.7) | 20.3±7.50(2.56 to 38.0) | 14.4±5.0 (n=6)(1.5 to 27.4) | 0.845 |
| Inflammation index | 0.88± 0.18(0.58 to 1.58) | 0.93±0.20 (n=7)(0.56 to 1.30) | 1.07±1.12 (7)(0.56 to 1.30) | 0.71 |
Data are mean±SE (95%CI). p=one-way ANOVA and Tukey post-tests.