Abstract: TH-PO1024
Identifying Patients Who Would Benefit of a Nephrology Workup for Diagnosis of CKD After an Episode of Preeclampsia
Session Information
- Women's Health and Kidney Diseases
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Women's Health and Kidney Diseases
- 2200 Women's Health and Kidney Diseases
Authors
- Carta, Simona, Universita degli Studi di Cagliari, Cagliari, Sardinia, Italy
- Gianferrari, Matteo, Universita degli Studi di Milano, Milan, Lombardy, Italy
- Fois, Antioco, Centre Hospitalier du Mans, Le Mans, Pays de la Loire, France
- Torreggiani, Massimo, Centre Hospitalier du Mans, Le Mans, Pays de la Loire, France
- Chatrenet, Antoine, Centre Hospitalier du Mans, Le Mans, Pays de la Loire, France
- Cabiddu, Gianfranca, Universita degli Studi di Cagliari, Cagliari, Sardinia, Italy
- Piccoli, Giorgina B., Centre Hospitalier du Mans, Le Mans, Pays de la Loire, France
Background
Preeclampsia (PE) is an hypertensive disorder of pregnancy defined by the combination of hypertension with onset after 20 weeks of gestation (GW) and at least one sign of renal, hepatic, central nervous system, or hematologic impairment. PE is associated with an increased risk of developing chronic hypertension, cardiovascular diseases and chronic kidney disease (CKD). Prevalence of undiagnosed CKD is reported as high in the cohort of women who have experienced PE. This study aimed to assess the prevalence of CKD in women undergoing a biochemical, clinical and imaging nephrology work-up after PE and explore the possibility of identifying those at higher risk of CKD based on PE characteristics, baseline and post-partum biochemical data.
Methods
Study participants were women who experienced PE referred to an outpatient nephrology clinic in Le Mans, France and Cagliari, Italy. The diagnosis of CKD was established and confirmed 6-12 months after delivery.
A total of 543 patients with at least 2 kidney function assessment, kidney imaging and complete birth data were analyzed (404 from Le Mans, 139 from Cagliari). Women were classified as: affected by CKD; without CKD; unclear diagnosis (persistent microalbuminuria or minor alterations in the kidney morphology at ultrasound imaging). Outcomes were analyzed by univariable and multivariable analysis.
Results
Median age at delivery was 31.4 years, 51.2% nulliparous, 28.7% obese, 74.8% White. Overall, 29.5% were diagnosed with CKD, in 40.3% CKD was reasonably excluded, and diagnosis was unsure in 30.2%. The main diagnoses were interstitial diseases in Le Mans (42.2%) and glomerular diseases in Cagliari (39%). Age, BMI, gestational age and PE severity were not associated with CKD diagnosis. While hypertension and proteinuria were associated with CKD diagnosis, proteinuria was present in about 30% the cases and hypertension in 54%, showing a too low sensitivity to be of use for cases to be referred to the nephrologist.
Conclusion
A nephrology work-up may identify CKD in about one third of women undergoing evaluation after an episode of PE; in the absence of baseline, pregnancy related and clinical characteristics predictive of the presence of CKD, we suggest offering nephrology workup to all women after PE.