Abstract: FR-PO0076
Trends and Disparities in Atrial Fibrillation and AKI-Related Mortality in the United States, 1999-2023
Session Information
- AKI: Epidemiology, Risk Factors, and Prevention
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 101 AKI: Epidemiology, Risk Factors, and Prevention
Authors
- Ali, Muhammad, Dow International Medical College, Karachi, Sindh, Pakistan
- Nasir, Anas, Sheikh Zayed Medical College, Rahim Yar Khan, Punjab, Pakistan
- Fatima, Hurmat, Foundation University Medical College, Islamabad, Islamabad Capital Territory, Pakistan
- Hussain, Dania, United Medical and Dental College, Karachi, Sindh, Pakistan
- Rahman, Saif Ur, Bacha Khan Medical College, Mardan, N.W.F.P, Pakistan
- Ghafur, Sadia, United Medical and Dental College, Karachi, Sindh, Pakistan
- Bakhsh, Rayyan Mohammad Makki, Foundation University Medical College, Islamabad, Islamabad Capital Territory, Pakistan
- Arshad, Muhammad Saad, United Medical and Dental College, Karachi, Sindh, Pakistan
- Ali, Irtiza, Texas A&M University, College Station, Texas, United States
Background
Atrial Fibrillation (AF) and acute kidney injury (AKI) are growing causes of mortality in the United States. We analyze the trends of the bidirectional relationship between AF and AKI in terms of their mortality in adults ≥65 years from 1999-2023. Understanding their shared mortality trends would help enhance management and patient outcomes.
Methods
The CDC WONDER Multiple Cause-of-Death Public Use records from 1999 to 2023 were used to analyze mortality trends in adults ≥65 years using ICD-10 codes N17 (AKI) and I48 (AF). Age-adjusted mortality rates (AAMRs) per 100,000 people, along with annual percent change (APC) and average annual percent change (AAPC), were calculated using Joinpoint regression software. Data were stratified by year, along with important demographic and regional subgroups.
Results
115,372 AKI and Afib-related deaths occurred from 1999 to 2023. There was an overall increase in the AAMR from 3.2 in 1999 to 23.9 in 2023 (AAPC: 8.9; 95%CI: 7.9 to 11.0). Significant disparities in mortality among different demographic and regional distributions were noted. AAMR increased the most in men (AAPC: 8.17; 95%CI: 6.8 to 9.8), rural areas (AAPC: 7.8; 95%CI: 7.1 to 8.6), non-Hispanic Whites (AAPC: 9.7; 95%CI: 8.7 to 11.7), the 65-74 years age group (AAPC: 9.3; 95%CI: 8.3 to 10.7), and Southern regions (AAPC: 9.5; 95%CI: 8.4 to 11.7).
Conclusion
AKI and AF-related mortality have been rising from 1999 to 2023, highlighting the necessity for focused research into strategic interventions to tackle disparities in access to healthcare to improve mortality.