Abstract: TH-PO0952
Post-Kidney Transplant Outcomes of Patients with Scleroderma from the Scientific Registry of Transplant Recipients (SRTR) Database, 1987-2024
Session Information
- Transplantation: Clinical - Glomerular Diseases, Infections, and Rejection
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 2102 Transplantation: Clinical
Authors
- Yasmin, Farah, Yale School of Medicine, New Haven, Connecticut, United States
- Wilson, Francis Perry, Yale School of Medicine, New Haven, Connecticut, United States
- Kuppachi, Sarat C., The University of Iowa Hospitals and Clinics Department of Internal Medicine, Iowa City, Iowa, United States
- Kumar, Abhishek, Yale School of Medicine, New Haven, Connecticut, United States
Background
Systemic sclerosis (SSc) can lead to end-stage kidney disease (ESKD) requiring transplant, yet outcomes for SSc remain underexplored.
Methods
Adult SSc patients (≥18 years) who underwent kidney transplantation (1987-2024) were identified from the SRTR database. Primary outcomes included patient survival and death-censored graft survival. Kaplan-Meier analysis was used to estimate survival functions, and multivariable Cox proportional hazards models were employed to identify factors associated with both outcomes.
Results
Among 3,750,323 transplant recipients (3,817 with SSc), SSc patients were younger (median age: 33 vs. 49 yrs; p<0.001) and 54% males.
Outcomes
Mortality: 1.0% (SSc) vs. 3.1% (p<0.001)
Graft failure: 3.7% vs. 3.8% (p=0.818)
Graft thrombosis: 1.2% vs. 0.8% (p=0.312)
Infection: 1.2% vs. 3.2% (p=0.033)
Chronic rejection: 6.1% vs. 6.9% (p=0.784)
Acute rejection: 15.1% vs. 6.4% (p=0.003)
SSc status was not significantly associated with mortality (HR 0.696; p=0.115) and graft failure (HR 0.92; p=0.474) after adjusting for female sex, recipient's and donor’s age, donor type, cold ischemic time, recipient’s Cr and pre-transplant dialysis. Cox interaction analysis revealed a statistically significant interaction between donor age and mortality in SSc (HR: 0.97; p=0.024). Figs. 1A and B shows results of survival analyses.
Conclusion
Graft survival and mortality in SSc patients was comparable to patients without SSc. Donor age was linked to higher mortality overall, this effect was attenuated in SSc, suggesting other contributing factors that warrant further investigation.
Fig 1 (A). Patient survival and (B) Graft survival for SSc vs. non-SSc patients undergoing kidney transplantation (p- patient survival =0.0216; p- graft survival=0.049).