Abstract: SA-PO0802
Fraction of Kidney Transplant Recipients with IgAN Differs by Race/Ethnicity Across the United States: A 38-Year Population-Based Analysis
Session Information
- Glomerular Research: Design, Registries, Surveys, and Epidemiology
November 08, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Belasy, Ahmed Roshdy Mansour Ali, Mayo Foundation for Medical Education and Research, Scottsdale, Arizona, United States
- Jaramillo, Andrés, Mayo Foundation for Medical Education and Research, Scottsdale, Arizona, United States
- Thomas, Leslie F., Mayo Foundation for Medical Education and Research, Scottsdale, Arizona, United States
- Gragert, Loren, Tulane University, New Orleans, Louisiana, United States
- Hacke, Katrin, Mayo Foundation for Medical Education and Research, Scottsdale, Arizona, United States
- Shaffi, Saeed Kamran, Mayo Foundation for Medical Education and Research, Scottsdale, Arizona, United States
Background
IgA Nephropathy (IgAN) is one of the leading causes of glomerulonephritis worldwide. The incidence of IgAN varies among global populations and ethnic groups, likely due to a combination of genetic and environmental factors. We used a large dataset to evaluate differences among US ethnic groups in the fraction of kidney transplant recipients diagnosed with IgAN.
Methods
We conducted a cross-sectional study using the 1987 to 2024 data from the Scientific Registry of Transplant Recipients (SRTR), which included patients who had transplantation due to end-stage kidney disease attributed to IgAN. State-level data on ethnic group proportions were obtained from the U.S. Census for 2005, a year midway between 1987 and 2024. For each state, we divided the transplants by ethnicity with the total number of transplants to calculate the ethnicity-stratified fraction of transplant recipients diagnosed with IgAN. For each state, we calculated the population fraction for each ethnicity, normalized the ethnicity-stratified fractions to their population share, and graphically displayed them.
Results
In a large cohort (n = 22,084), Asians received kidney transplants for IgAN 4.3 times more than their population share, followed by Pacific Islanders and Native Americans (Fig 1a & 1b). Blacks were underrepresented, while Whites matched their population proportion.
Conclusion
The population normalizrd proportion of IgAN-related kidney transplants varied by ethnicity, with Asians, Pacific Islanders, and Native Americans overrepresented and Blacks underrepresented. This suggests a higher IgAN incidence in the former groups. Further research is needed to explore underlying genetic and environmental factors.