Abstract: FR-PO0957
Long-Term Clinical and Biochemical Outcomes in Living Kidney Donors at a Tertiary Care Center
Session Information
- Transplantation: Clinical - Pretransplantation, Living Donation, and Policies
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 2102 Transplantation: Clinical
Authors
- Delgado Avila, Brenda Guadalupe, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, CDMX, Mexico
- Aguirre Anaya, Luis Iván, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, CDMX, Mexico
- García Ruiz, Lenin Alberto, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, CDMX, Mexico
- Marino-Vazquez, Lluvia A., Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, CDMX, Mexico
- Morales-Buenrostro, Luis E., Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, CDMX, Mexico
Background
Donation nephrectomy leads to loss of renal mass and reduced glomerular filtration rate. Assessing long-term outcomes is crucial to ensure donor safety.
Methods
We conducted a retrospective cohort study using the Electronic Medical Record from the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. We included 303 living kidney donors ≥18 years old who donated between 2000 and 2024. Donors were stratified by time since donation into three groups: <10 years (n=97), 10–20 years (n=121), and >20 years (n=85).
Results
The mean age of our cohort was 53.9 ± 13.1 years, with an average BMI of 26.97 ± 4.57 kg/m2. Mean weight gain was 4.13 ± 8.64 kg (6.41% ± 13.78%). Notably, 24.1% (n=73) of the donors had obesity (BMI ≥30 kg/m2). Current mean estimated Glomerular Filtration Rate (eGFR) was 76.84 ±16.86 ml/min/1.73 m2; mean urine albumin to creatinine ratio (uACR) was 21.85 ± 66.71 mg/g. uACR increased in donors with longer time since donation (p=0.0045). Prevalence of hypertension increased with time since donation (p < 0.001), reaching 34.1% in > 20 years post-donation. Type 2 diabetes and albuminuria showed a trend toward higher prevalence in the groups with longer time since donation (p = 0.092 and p = 0.0045, respectively). No significant differences were seen in dyslipidemia or cardiovascular events (stroke, acute myocardial infarction, or peripheral arterial disease)
Conclusion
Living kidney donors are at risk for developing hypertension and albuminuria over time, even without major declines in eGFR. These findings highlight the importance of long-term follow-up in this population to detect and manage emerging risk factors for chronic kidney disease.