Kidney Week

Abstract: FR-PO1170

Kidney Screening with Albuminuria Measurement in First-Degree Relatives of Patients with ESRD: Timely Detection to Prevent Chronic Kidney Damage

Session Information

• CKD: Screening, Diagnosis, Serum and Urine Biomarkers, and Scoring Indices
  November 07, 2025 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Rodríguez Ibarra, Kenya Y, Hospital Universitario Dr. José Eleuterio González, Monterrey, N.L., Mexico

Kenya Y Rodríguez Ibarra, MD

• Olivo, Mara Cecilia, Hospital Universitario Dr. José Eleuterio González, Monterrey, N.L., Mexico

Mara Cecilia Olivo, MD

• Gomez Villarreal, Juan Pablo, Hospital Universitario Dr. José Eleuterio González, Monterrey, N.L., Mexico

Juan Pablo Gomez Villarreal, MD

• Borbolla-Flores, Paola, Hospital Universitario Dr. José Eleuterio González, Monterrey, N.L., Mexico

Paola Borbolla-Flores, MD

• Arteaga Muller, Giovanna Y., Hospital Universitario Dr. José Eleuterio González, Monterrey, N.L., Mexico

Giovanna Y. Arteaga Muller, MD

• Lopez-Guzman, Sofia, Hospital Universitario Dr. José Eleuterio González, Monterrey, N.L., Mexico

Sofia Lopez-Guzman

• Treviño Partida, Lesly Anette, Hospital Universitario Dr. José Eleuterio González, Monterrey, N.L., Mexico

Lesly Anette Treviño Partida

• Rizo Topete, Lilia Maria, Hospital Universitario Dr. José Eleuterio González, Monterrey, N.L., Mexico

Lilia Maria Rizo Topete, MD

Background

Albuminuria is an early marker of kidney damage and plays a key role in preventing chronic kidney disease (CKD). First-degree relatives (FDR) of patients with end-stage renal disease (ESRD) have up to twice the risk of developing kidney dysfunction compared to those without a family history.

Methods

This observational, cross-sectional, descriptive study, aimed to evaluate the prevalence of albuminuria as a renal risk marker in FDR of patients in Renal Replacement Therapy (RRT). Study conducted at the Hospital Universitario “Dr. José Eleuterio González”, Mty., Mexico. Participants were adults with confirmed FD kinship. Clinical screening included anthropometric measurements, vital signs, and POC device, plus urine collection for quantitative microalbuminuria assessment using the Getein 1100 immunofluorescence analyzer. Albuminuria was defined as ≥20 mg/g. Data were analyzed using Python (v3.13).

Results

Among 45 FD relatives of patients in RRT, albuminuria was identified in 10 individuals who were unaware of having markers of kidney damage, representing 22.2% of this population. 15.6% (7) were male and clinical and laboratory parameters are shown in Table 1.
Other findings include the prevalence of hypertension and type 2 diabetes was 28.9% (13). Additionally, 20% (9) reported peripheral circulatory disease and 22.2% (10) had a history of proteinuria or hematuria. No significant differences were found between participants with or without elevated albuminuria regarding age, eGFR, blood pressure, creatinine, weight, or other clinical factors (all p > 0.1). The dipstick test showed an overall accuracy of 82%, with a sensitivity of 91% for negative results and 50% for positive results.

Conclusion

It is highly relevant to establish the association between FDR and risk factors, as well as to promote screening strategies that help predict the risk of CKD, such as the detection of albuminuria.

Funding

• Clinical Revenue Support

Digital Object Identifier (DOI)

• doi: 10.1681/ASN.2025dtpyvcg0