Abstract: FR-PO0878
Role of Environmental Exposures in the Prognosis of IgAN in the Saint Louis Area
Session Information
- Glomerular Outcomes: From Proteinuria to Prognosis
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Truong, Dzuy, Saint Louis University School of Medicine, St. Louis, Missouri, United States
- Aydin, Orhun, Saint Louis University, St. Louis, Missouri, United States
- DeLonais-Parker, Ava, Saint Louis University School of Medicine, St. Louis, Missouri, United States
- Rabideau, Kate, Saint Louis University School of Medicine, St. Louis, Missouri, United States
- Befeler, Jaime, Saint Louis University School of Medicine, St. Louis, Missouri, United States
- Unes, Meghan Marie, Saint Louis University School of Medicine, St. Louis, Missouri, United States
- Lentine, Krista L., Saint Louis University, St. Louis, Missouri, United States
- Caliskan, Yasar, Saint Louis University School of Medicine, St. Louis, Missouri, United States
Background
IgA nephropathy (IgAN) is a common form of primary adult glomerulonephritis. The pathogenesis of IgA nephropathy is complex and includes genetics and environmental factors. We aim to elucidate the role of patient geographical location in the incidence of IgAN and progression to end stage kidney disease (ESKD) in the Saint Louis area.
Methods
A retrospective chart review study was conducted including patients diagnosed with IgAN and seen by a SSM Saint Louis University Hospital within the last 12 months. Data was analyzed to study the linkages between patients’ ZIP code and disease outcomes such as development of ESKD and last visit GFR.
Results
40 patients were included in this study with a mean age at diagnosis of 42.6 years (SD = 6.5). 55% of patients were identified as male. Via Geographically Weighted Regression Model (GWRM), initial CKD-EPI eGFR was a global predictor of ESKD development while BMI and age predicted ESKD development for patients in ZIP codes associated with downtown Saint Louis. Using a GWRM, initial eGFR, initial serum creatinine, and age at diagnosis showed a North-South trend as predictors of last visit eGFR. BMI has a East-West trend on its impact on eGFR outcomes.
Conclusion
Based on these findings, there are geographical trends in the development of ESKD and eGFR in IgAN patients within the Saint Louis Area. Further studies can be conducted to investigate environmental data stratified by ZIP codes (e.g. heavy metals, air pollution, etc.) that may contribute to these geographical biases.
Table 1. Baseline Characteristics
| Variable | Mean | Standard Deviation | Median |
| BMI | 30.03 | 6.47 | 29.88 |
| Age at Diagnosis | 42.62 | 15.16 | 43 |
| CKD-EPI GFR (ml/min/1.73m2) | 48.7 | 34.17 | 38 |
| Urine protein creatinine ratio (g/g) | 1.77 | 2.08 | 0.45 |
| Serum albumin level | 3.63 | 0.65 | 3.7 |
| Serum uric acid level | 6.96 | 2.31 | 6.9 |
| Hemoglobin level | 12.24 | 2.53 | 11.8 |