Abstract: TH-PO1077
Prevalence and Mortality of Critically Ill Patients with CKD in Peru
Session Information
- CKD: Epidemiology, Risk Factors, and Other Conditions
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Nombera, Natalia R., The University of Alabama at Birmingham, Birmingham, Alabama, United States
- Fernandez Merjildo, Diana, Universidad Peruana Cayetano Heredia, Lima District, Lima Region, Peru
- Leon, Cristian Paul, Hospital Nacional Cayetano Heredia, Lima District, Lima Region, Peru
Background
Chronic kidney disease (CKD) is a progressive condition with high global prevalence. In patients hospitalized in intensive care units (ICU), CKD increases the risk of acute kidney injury (AKI), need for renal replacement therapy, and mortality. In Peru, CKD management remains fragmented and access to dialysis is limited, highlighting significant challenges in providing adequate care. This study aims to determine the prevalence and mortality among critically ill patients with CKD admitted to a Peruvian ICU.
Methods
We conducted a cross-sectional study at Hospital Nacional Cayetano Heredia from 2016 to 2024. Patients aged 18 years or older admitted to the ICU with a prior diagnosis of CKD, as defined by KDIGO guidelines, were included. Clinical and demographic data were collected, including acute conditions that developed during the ICU stay and survival status. Descriptive statistics summarized the data. Exploratory analysis of time-dependent variables was performed using Cox proportional hazards models and Kaplan–Meier survival curves to identify factors associated with mortality.
Results
A total of 329 patients were included. The median age was 57 years (IQR: 44–66), and 55% were female. At ICU admission, 36.8% had a surgical condition, 26.4% died during hospitalization, and the median ICU stay was 6 days (IQR: 3–14). Septic shock was present in 29.8%, acute respiratory failure on mechanical ventilation in 86.3%, and AKI in 24.9%. The overall prevalence and mortality ratios were 5.3% and 26.4% respectively. The median survival time was 28 days. Shock at admission was independently associated with increased mortality (HR: 2.82; 95% CI: 1.78–4.46; p < 0.001). No other significant associations were found.
Conclusion
In this cohort, CKD prevalence rates were comparable to international data, yet mortality remained markedly high. Shock at admission was the only predictor of mortality. This study represents the most comprehensive evaluation of critically ill CKD patients in Peru to date and highlights the urgent need for targeted interventions to improve outcomes in this high-risk population.