Abstract: FR-PO0077
Trends and Disparities in AKI and Acute Respiratory Failure (ARF)-Related Mortality in the United States, 1999-2023
Session Information
- AKI: Epidemiology, Risk Factors, and Prevention
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 101 AKI: Epidemiology, Risk Factors, and Prevention
Authors
- Ali, Muhammad, Dow International Medical College, Karachi, Sindh, Pakistan
- Ahmad, Wajdan, Al-Tibri Medical College, Karachi, Sindh, Pakistan
- Nasir, Anas, Sheikh Zayed Medical College, Rahim Yar Khan, Punjab, Pakistan
- Hussain, Dania, United Medical and Dental College, Karachi, Sindh, Pakistan
- Imran, Haider, Foundation University Medical College, Islamabad, Islamabad Capital Territory, Pakistan
- Fatima, Eshal, Foundation University Medical College, Islamabad, Islamabad Capital Territory, Pakistan
- Wajih, Yusra, Foundation University Medical College, Islamabad, Islamabad Capital Territory, Pakistan
- Khan, Habiba Nadeem, Central Park Medical College, Lahore, Punjab, Pakistan
- Ali, Irtiza, Texas A&M University, College Station, Texas, United States
Background
Mortality rates due to Acute Kidney Injury (AKI) and Acute Respiratory Failure (ARF) among the U.S. population are higher than the general population. This study seeks to examine mortality trends in adults ≥65 years, taking into account demographic and geographic factors between 1999 and 2023.
Methods
The CDC WONDER Multiple Cause-of-Death Public Use records from 1999 to 2023 were used to analyze mortality trends amongst adults ≥65 years using ICD-10 codes for AKI (N17) and ARF (J80, J96.0, and J96.9). Age-adjusted mortality rates (AAMRs) per 100,000 people, along with annual percent change (APC) and average annual percent change (AAPC) were stratified by year, along with demographic and geographic subgroups using Joinpoint regression software.
Results
278,182 AKI and AFR-related deaths occurred from 1999 to 2023. Annual overall trends illustrate a significant increase in the AAMR, from 8.55 in 1999 to 51.75 in 2023 (AAPC: 8.5; 95%CI: 7.6 to 10.2). Women had a higher rate of increase in AAMR (AAPC women: 8.83; 95%CI: 8.0 to 10.2, AAPC men: 8.0; 95%CI: 7.0 to 10.3). Racially, non-Hispanic Black/African Americans had the highest rate of increase in AAMR (AAPC: 8.9; 95%CI: 8.00 to 10.5) compared to other races. Regionally, the south had the highest rate of increase in AAMR (AAPC: 8.7; 95%CI: 7.7 to 11.2); likewise, rural areas saw the highest rate of increase in AAMR compared to urban areas (AAPC rural: 9.4; 95%CI: 8.5 to 10.8, AAPC urban: 7.5; 95%CI: 6.0 to 9.4). State-wise, California had the highest percentage of deaths throughout the study duration at 13.53%.
Conclusion
Upward trends in AAMR among patients with AKI and ARF in the United States from 1999 to 2023 are a cause for concern, additional research is essential to address these trends and improve health outcomes and address disparities.