Abstract: FR-PO1086
Gut Microbial Networks Respond to Cranberry Extract (Vaccinium macrocarpon) Supplementation in Nondialysis-Dependent Patients with CKD
Session Information
- Health Maintenance, Nutrition, and Metabolism
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Resende Teixeira, Karla Thaís, Universidade Federal Fluminense, Niterói, RJ, Brazil
- Moreira, Laís Gouveia, Universidade Federal Fluminense, Niterói, RJ, Brazil
- Kemp, Julie Ann, Universidade Federal Fluminense, Niterói, RJ, Brazil
- de Almeida, Pedro Ivo Neves, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
- Borges, Natalia Alvarenga, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
- de Paiva, Bruna Regis, Universidade Federal Fluminense, Niterói, RJ, Brazil
- Trugilho, Liana, Universidade Federal Fluminense, Niterói, RJ, Brazil
- Brum, Isabela de Souza da Costa, Universidade Federal Fluminense, Niterói, RJ, Brazil
- Leal, Viviane Oliveira, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
- Santos, Henrique Fragoso dos, Universidade Federal Fluminense, Niterói, RJ, Brazil
- Mafra, Denise, Universidade Federal Fluminense, Niterói, RJ, Brazil
Background
Individuals with CKD commonly exhibit dysbiosis linked to clinical complications. Researchers have been exploring therapeutic strategies to modulate the gut microbiota, such as the prebiotic potential of cranberries. This study aimed to evaluate the impact of cranberry supplementation on the gut microbiota of individuals with CKD.
Methods
This study is a secondary analysis of a randomized, double-blind, clinical trial involved 15 non-dialysis CKD patients (stages 3 and 4). Participants in the cranberry group (n=8) received 500 mg capsule of dry cranberry extract twice daily for two months, while those in the placebo group (n=7) received capsules containing corn starch. The microbiota analysis was performed using 16S ribosomal RNA amplicons from the V4-V5 region. Co-occurrence networks were built and assessed using SparCC and the SpiecEasi package in R. Key microbial hubs were identified through PageRank.
Results
Bacillota and Bacteroidota were the dominant phyla, with Bacteroides, Prevotella, Alistipes, and UCG.002 being the most abundant genera. No significant changes were observed in alpha or beta diversity after interventions. Interestingly, an increase in bacterial network connections was observed in the cranberry group (p=0.03), while the placebo showed a reduction (p=0.03), as shown in figure 1.
Conclusion
The increases in bacterial networks suggest a potential influence on microbial community dynamics. It can indicate early shifts in ecological interactions that precede compositional changes.
Funding
- Government Support – Non-U.S.