Abstract: TH-PO1163
Relevance of Blood Cellular Indices in Relation to Thromboinflammatory, Cardiac, and Kidney Biomarkers in Patients with ESRD
Session Information
- CKD: Mechanisms, AKI, and Beyond - 1
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2303 CKD (Non-Dialysis): Mechanisms
Authors
- Konczak, Katherine Elizabeth, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, United States
- Siddiqui, Fakiha, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, United States
- Kaufmann, Ella, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, United States
- Rohde, Luke, Saint Louis University, St. Louis, Missouri, United States
- Nunez, Roy D, Loyola University Chicago, Chicago, Illinois, United States
- Koura, Simran, Loyola University Medical Center, Chicago, Illinois, United States
- Hoppensteadt, Debra, Loyola University Medical Center, Chicago, Illinois, United States
- Vellanki, Kavitha, Loyola University Medical Center, Chicago, Illinois, United States
- Bansal, Vinod K., Loyola University Medical Center, Chicago, Illinois, United States
- Fareed, Jawed, Loyola University Medical Center, Chicago, Illinois, United States
Background
CVD, including cardiorenal syndrome (CRS), is highly prevalent in ESRD patients. Elevated levels of thrombo-inflammatory, cardiac, and renal biomarkers may be associated with CVD and CKD progression; additionally, CBC-derived cellular indices have shown potential in predicting morbidity and mortality in CVD and CKD that may be applied to ESRD and CRS.
Methods
Biomarker levels in plasma samples from 70 patients with ESRD and 10 controls were quantified using ELISA. Blood cellular indices were calculated from patient CBC values; adult reference values were obtained from healthy donors. Additional parameters and medical history were obtained from the medical record. Statistical analyses were performed using non-parametric tests.
Results
Many CVD comorbidities were prevalent among ESRD patients. Cellular indices values aligned with the inflammation and anemia present in ESRD. ESRD samples exhibited a statistically significant increase in all biomarker levels compared to control samples. There were no statistically significant differences in biomarker levels between ESRD with and without CRS. Biomarker and cellular indices values for ESRD exhibited varying degrees of correlation, but the ESRD with CRS subgroup displayed a high degree of correlation.
Conclusion
ESRD is a chronic inflammatory condition with involvement of numerous proteins and cytokines with hemodynamics consequences and CVD manifestations. However, CRS is an uncommon and complex condition, with 10% prevalence in the cohort. Correlation changes in blood cellular indices and biomarkers may be of diagnostic and prognostic value.
Funding
- Other NIH Support