Abstract: FR-PO1090
Effect and Safety of an Individualized Diet with Oral Supplementation on Nutritional Status and Quality of Life in Patients with Nondialysis-Dependent CKD
Session Information
- Health Maintenance, Nutrition, and Metabolism
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Alvarado, Paola Azucena, Nin Institute, Guadalajara, Jalisco, Mexico
- Cisneros Hernández, Ari, Nin Institute, Guadalajara, Jalisco, Mexico
- García Rodríguez, Xunaxi Nahomi, Nin Institute, Guadalajara, Jalisco, Mexico
- Chavez, Jonathan, Universidad de Guadalajara, Guadalajara, Jal., Mexico
Background
In chronic kidney disease (CKD), there is a high prevalence of nutritional disorders and alterations in body composition, which are associated with increased morbidity and mortality. Epidemiological studies report that 50% of patients experience malnutrition. The main contributing factor is an insufficient intake of energy and macronutrients, which is further aggravated by gastrointestinal symptoms that hinder meeting nutritional requirements.
Methods
Randomized controlled clinical trial with two intervention groups, both receiving nutritional therapy. One group received a once daily high calorie, low-protein oral supplement. Participants were non-dialysis patients who met criteria for protein energy wasting. Blood and urine biochemical analyses were performed, as well as body composition assessments at three time points. Nutritional risk screening was conducted using the Subjective Global Assessment, and quality of life was evaluated with the KDQOL-36 questionnaire.
Results
For the preliminary results, the baseline and final intervention periods were analyzed. A total of 20 subjects were evaluated: 8 men and 12 women, with a mean age of 59 years. Average energy intake was 31.26 ± 2.54 kcal/kg/day, with the supplement contributing an additional 15 ± 1.5% of total energy intake. Protein intake was ensured at 0.8 g/kg/day, with 14.2 ± 1.2 g provided through the supplement. At baseline, 45% of participants rated their appetite as fair, while at the end, 7 participants (80%) rated it as good (p = 0.056). Constipation was present in 5 subjects (25%) at baseline and improved to 2 subjects (10%) by the end. Clinical improvements were observed in biochemical markers, including reductions in uric acid and slight increases in HDL cholesterol, albumin, iron, and transferrin. Phosphorus, sodium, and potassium levels remained stable. PCR levels decreased after the intervention. Although the trend suggests a clinically relevant reduction, the changes were not statistically significant.
Conclusion
This analysis shows positive clinical changes associated with an individualized diet combined with a specialized oral supplement. Statistically significant improvements were observed in parameters such as increased appetite and reduction of gastrointestinal symptoms.