Abstract: FR-PO0879
Sex-Based Differences in Clinical Manifestations and Outcomes of Lupus Nephritis: Insights from a Mexican Cohort
Session Information
- Glomerular Outcomes: From Proteinuria to Prognosis
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Fonseca Chávez, Alfredo, Department of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
- Soto, Virgilia, Department of Pathology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
- Ayala Guzmán, César Iván, Universidad Iberoamericana, Mexico City, CDMX, Mexico
- Campos Núñez, Guadalupe, Department of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
Background
Lupus nephritis (LN) affects up to 75% of patients with systemic lupus erythematosus (SLE). Although SLE is less common in men, studies suggest they may experience severe disease. Most data come from Caucasian populations; evidence from Latins is limited.
Methods
Retrospective cohort of LN patients (2014–2023), grouped by sex. Follow-up continued until kidney transplantation, renal replacement therapy (RRT), death, or last evaluation. Statistical analysis included t-tests, Mann-Whitney U, and chi-square tests with p<0.05.
Results
50 patients (25 men), mean age 32.3 years. Women had more alopecia (p= 0.018). Nephrotic syndrome was more frequent in women and nephritic in men (p= 0.003). Men had higher inflammatory markers, lower complement levels, and higher ANA titers. Crescents were more common in men and thrombotic microangiopathy in women. Women had higher relapse rates (p=0.003) and better post-relapse remission (90% vs 40%; p= 0.019). Men showed a trend toward worse renal outcomes. Mortality was similar.
Conclusion
Men with LN showed greater inflammatory activity and lower remission rates, while women had more relapses but better treatment response. Sex-based approaches in LN care may improve outcomes.