Abstract: FR-PO0078
Trends and Disparities in AKI and Septicaemia-Related Mortality in the United States, 1999-2023
Session Information
- AKI: Epidemiology, Risk Factors, and Prevention
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 101 AKI: Epidemiology, Risk Factors, and Prevention
Authors
- Ali, Muhammad, Dow International Medical College, Karachi, Sindh, Pakistan
- Nasir, Anas, Sheikh Zayed Medical College, Rahim Yar Khan, Punjab, Pakistan
- Fatima, Hurmat, Foundation University Medical College, Islamabad, Islamabad Capital Territory, Pakistan
- Rahman, Saif Ur, Bacha Khan Medical College, Mardan, N.W.F.P, Pakistan
- Hussain, Dania, United Medical and Dental College, Karachi, Sindh, Pakistan
- Khurshid, Huzaifa, Khyber Medical College, Peshawar, N.W.F.P, Pakistan
- Khan, Amal Shahzad, Foundation University Medical College, Islamabad, Islamabad Capital Territory, Pakistan
- Sher, Sarwat, Rehman Medical College, Peshawar, N.W.F.P, Pakistan
- Ali, Irtiza, Texas A&M University, College Station, Texas, United States
Background
Acute Kidney Injury (AKI) and septicaemia are interlinked, and research into their shared mortality trends in the United States is needed. Understanding the epidemiology and trends of populations afflicted with these diseases would significantly help enhance management and improve outcomes. We analyze AKI and septicaemia-related mortality in adults aged 65 and older from 1999 to 2023, with additional focus on demographic and geographic factors
Methods
The CDC WONDER Multiple Cause-of-Death Public Use records from 1999 to 2023 were used to analyze mortality trends amongst adults ≥65 years using ICD-10 codes for AKI (N17) and septicaemia (A02.1, A22.7, A26.7, A32.7, A40, A41, A42.7, and B37.7). Age-adjusted mortality rates (AAMR) per 100,000 people, along with annual percent change (APC) and average annual percent change (AAPC), were stratified by year, along with demographic and regional stratifications using Joinpoint regression software.
Results
308,161 AKI and septicaemia-related deaths occurred from 1999 to 2023. Overall, AAMR rose from 14.1 in 1999 to 48.5 in 2023. Significant disparities in mortality rates among different demographic and regional distributions were noted. AAMR increased the most in women (AAPC: 6.2; 95%CI: 5.6 to 7.1) compared to men, non-Hispanic Whites (AAPC: 6.3; 95%CI: 5.6 to 7.3) compared to other races, the West (AAPC: 6.9; 95%CI: 6.1 to 8.1) compared to other census regions, and rural areas (AAPC: 5.1; 95%CI: 4.5 to 6.0) versus urban areas.
Conclusion
An upward trajectory has been seen in AKI and septicaemia-related mortality from 1999 to 2023. This highlights the importance of advancing kidney health research to reduce these rates in the upcoming years.