Kidney Week

Abstract: FR-PO1172

Performance of the European Kidney Function Consortium Equation in the Indian Population with India-Specific Q Value and Constant

Session Information

• CKD: Screening, Diagnosis, Serum and Urine Biomarkers, and Scoring Indices
  November 07, 2025 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Kaur, Jaskiran, Post Graduate Institute of Medical Education and Research, Chandigarh, CH, India

Jaskiran Kaur, PhD

• Kaur, Rupinder, Post Graduate Institute of Medical Education and Research, Chandigarh, CH, India

Rupinder Kaur, MSW

• Agnihotri, Pratima, Post Graduate Institute of Medical Education and Research, Chandigarh, CH, India

Pratima Agnihotri, MSW

• Kumar, Vivek, Post Graduate Institute of Medical Education and Research, Chandigarh, CH, India

Vivek Kumar, MD, MBBS

• Yadav, Ashok Kumar, Post Graduate Institute of Medical Education and Research, Chandigarh, CH, India

Ashok Kumar Yadav, PhD

• Jha, Vivekanand, The George Institute for Global Health, New Delhi, Delhi, India

Vivekanand Jha

• Kohli, Harbir Singh, Post Graduate Institute of Medical Education and Research, Chandigarh, CH, India

Harbir Singh Kohli, MD

Background

The recently developed European Kidney Function Consortium (EKFC) equation estimates GFR using a rescaling factor (Q value),representing the median serum creatinine (SCr) or cystatin C (CysC) level in healthy subjects. It has been derived in white European populations and its performance in Indian subjects is unknown. We derived Indian-specific Q values and median measured GFR (mGFR) from healthy individuals and investigated the performance of the EKFC equation using the original and India-specific values.

Methods

This cross-sectional study includes healthy adults and patients with CKD. GFR was measured using plasma iohexol clearance using multiple sampling (at 120, 180 and 240 minutes). India-specific Q values for SCr and CysC were derived from healthy adults. mGFR (constant) was derived from healthy adults < 40 years. Performance was assessed using bias, precision, and accuracy (root mean square error [RMSE], and P30 [%eGFR within 30% of mGFR]).

Results

A total of 1,180 participants were enrolled, consist of 621 healthy participants and 559 with chronic kidney disease (CKD). The mean age of the population was 48±12 years, with 49.6 % being males. Indian specific Q value for males and females was 0.82 and 0.65 respectively for SCr and 0.96 and 0.89 respectively for CysC. The constant was 90.68. The mean mGFR of the overall study population was 59.7±31.8 mL/min/1.73 m². Table 1 shows the performance of various EKFC equations. The original EKFCcr had a mean bias of –10.0 ± 20.9 mL/min/1.73 m² and P30 of 58%. Applying Indian-specific Q values improved bias and P30 modestly (EKFC_crcysIndQ, mean bias: –5.5; P30: 65%). Replacing the European constant with the Indian median mGFR further improved accuracy. The EKFCcr_mGFR showed the lowest bias and the highest P₃₀.

Conclusion

The EKFC equations with Indian specific Q values and constant showed better accuracy and agreement with measured GFR, supporting the need for population-specific validation to improve GFR estimation in the Indian Population.

Digital Object Identifier (DOI)

• doi: 10.1681/ASN.20255cbt1w58