Abstract: PUB292
Trends and Disparities in Hypertensive Kidney Disease and Atrial Fibrillation-Related Mortality in the United States, 1999-2023
Session Information
Category: Hypertension and CVD
- 1602 Hypertension and CVD: Clinical
Authors
- Ali, Muhammad, Dow International Medical College, Karachi, Sindh, Pakistan
- Nasir, Anas, Sheikh Zayed Medical College, Rahim Yar Khan, Punjab, Pakistan
- Ghafur, Sadia, United Medical and Dental College, Karachi, Sindh, Pakistan
- Hussain, Dania, United Medical and Dental College, Karachi, Sindh, Pakistan
- Khan, Ahmed Ali, Foundation University Medical College, Islamabad, Islamabad Capital Territory, Pakistan
- Khan, Amal Shahzad, Foundation University Medical College, Islamabad, Islamabad Capital Territory, Pakistan
- Imran, Haider, Foundation University Medical College, Islamabad, Islamabad Capital Territory, Pakistan
- Ali, Irtiza, Texas A&M University, College Station, Texas, United States
Background
Research regarding the shared mortality trends of hypertensive renal disease (HRD) and atrial fibrillation (AF) is limited, especially in the United States. We analyze HRD and AF-related mortality in adults ≥65 years from 1999 to 2023 with additional attention on demographic and geographic stratifications.
Methods
The CDC WONDER Multiple Cause-of-Death Public Use records (1999-2023) were used to analyze mortality trends amongst adults ≥65 years using ICD-10 codes for HRD (I12) and Atrial fibrillation (I48). Age-adjusted mortality rates (AAMRs) per 100,000 people, along with annual percent change (APC) and average annual percent change (AAPC), were stratified by year, along with demographic and regional subgroups using Joinpoint regression software.
Results
117,076 HRD and AF-related deaths occurred from 1999 to 2023. Overall, AAMR rose from 0.6 in 1999 to 29.2 in 2023 (AAPC: 18.0; 95%CI: 14.1 to 22.5). Men had higher average AAMR throughout, though both sexes had similar rates of increase (AAPC men: 17.8; 95%CI: 14.0 to 22.1, AAPC women: 17.8; 95%CI: 14.2 to 21.9). The West has the highest average AAMR throughout and the highest rate of increase (AAPC West: 18.2; 95%CI: 14.0 to 23.3, AAPC Midwest: 17.7; 95%CI: 12.6 to 23.0, AAPC South: 16.7; 95%CI: 12.8 to 21.6, AAPC Northeast: 15.9; 95%CI: 12.7 to 20.0).
Conclusion
Our findings reveal increasing HRD and AF-related mortality trends, with key disparities between sexes and the census regions. Implementing targeted public health initiatives to address these disparities is essential for decreasing mortality in at-risk communities.