Abstract: SA-OR045
Amino Acid Composition and Dietary-Induced Changes in Patients with CKD
Session Information
- Exploring Dietary, Exercise, and Microbiome Interventions in CKD
November 08, 2025 | Location: Room 360A, Convention Center
Abstract Time: 05:50 PM - 06:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Kim, So Mi, Dankook University Hospital, Cheonan-si, Chungcheongnam-do, Korea (the Republic of)
- Lee, Eun Kyoung, Dankook University Hospital, Cheonan-si, Chungcheongnam-do, Korea (the Republic of)
- Lee, Hwa Young, Jeju National University, Jeju-si, Jeju-do, Korea (the Republic of)
- Jang, Youngjoo, Dankook University Hospital, Cheonan-si, Chungcheongnam-do, Korea (the Republic of)
- Yi, Yongjin, Dankook University Hospital, Cheonan-si, Chungcheongnam-do, Korea (the Republic of)
Background
Protein restriction is commonly recommended for patients with chronic kidney disease (CKD), but limited research has examined amino acid profiles in these patients. This study aimed to investigate the basic amino acid composition in CKD patients and the changes in amino acids resulting from dietary modifications.
Methods
In this prospective randomized trial, 52 CKD patients were enrolled. 26 received a CKD-specific meal, and 26 received dietary education only. Amino acid levels were measured at baseline and after 56 days.
Results
A total of 45 patients completed the study. At baseline, deficiencies in essential amino acids were observed: histidine (56%), tryptophan (43.3%), isoleucine (8.3%), and lysine (3.3%). Non-essential amino acid deficiencies included tyrosine (13.3%), taurine (8.3%), and serine (6.7%). After 56 days, the CKD-specific meal group showed increases in all essential amino acids except tryptophan, and in all non-essential amino acids except tyrosine, compared to the education group. Glutamine and serine showed statistically significant improvements (Table 1).
Conclusion
Our study showed that the protein-restricted CKD-specific meal, designed according to guidelines, is more effective than dietary education alone in preventing amino acid deficiencies and promoting their increase. Further discussion is needed regarding the characteristics of each amino acid, and the relevance of CKD-specific diets and their efficacy.
Table 1. Changes in amino acid levels according to CKD diet in patients with CKD
| Education-only group | CKD-specific meal group | P-value | |
| Essential amino acids | |||
| Leucine | 10.81±30.24 | 2.55±29.61 | 0.141 |
| Isoleucine | -12.28±24.33 | -5.30±17.59 | 0.279 |
| Valine | -2.15±43.51 | 15.76±48.45 | 0.198 |
| Lysine | 4.13±41.09 | 17.96±54.45 | 0.343 |
| Treonine | 7.13±25.59 | 8.28±35.96 | 0.902 |
| Tryptophan | 0.72±10.41 | -2.90±14.84 | 0.350 |
| Histidine | 1.74±7.64 | 9.92±10.51 | 0.059 |
| Non-essential amino acids | |||
| Alanine | 9.93±103.42 | 55.21±133.49 | 0.212 |
| Glutamic acid | -1.17±26.72 | 0.51±27.64 | 0.836 |
| Glutamine | 34.48±60.12 | 80.24±65.46 | 0.019 |
| Serine | 2.42±21.54 | 19.34±23.10 | 0.015 |
| Tyrosine | 2.15±10.46 | 1.09±14.04 | 0.774 |