Abstract: SA-PO0205
Rising Mortality with Dual Burden: Trends in Kidney Cancer Deaths Attributable to Hypertensive Disease in the United States, 1999-2020
Session Information
- Onconephrology: MGRS, HSCT, Electrolytes, RCC, and More
November 08, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Onconephrology
- 1700 Onconephrology
Authors
- Sakariya, Dhrumil, Davao Medical School Foundation Poblacion District, Davao, Philippines
- Shah, Dhruvil K., Western Reserve Health Education, Warren, Ohio, United States
- Zinzala, Hardik, University of Perpetual Help System Dalta Jonelta Foundation School of Medicine, Las Pinas, Philippines
- Upadhyay, Devangi, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, India
- Patel, Vishva Chandrakant, GMERS Medical college and Civil Hospital, Ahmedabad, Gujarat, India
- Desai, Hardik Dineshbhai, Gujarat Adani Institute of Medical Sciences, Bhuj, India
- Patel, Juhi, GMERS Medical college and Civil Hospital, Ahmedabad, Gujarat, India
- Amin, Vishrant, GMERS Medical college and Civil Hospital, Ahmedabad, Gujarat, India
Background
Hypertensive disease (HD) is an emerging contributor to mortality from kidney cancer(KC), yet disaggregated population-level trends remain poorly defined.
Methods
We analyzed CDC WONDER Multiple Cause of Death data (1999–2020) for deaths with KC as the underlying cause and HD as a contributing cause. Annualized percentage change (APC) was calculated using log-linear regression, stratified by sex, race, Hispanic origin, urbanization, and age.
Results
Overall deaths increased from 3,540 in 1999 to 13,232 in 2020, corresponding to an APC of +6.79%. Male deaths rose from 217 to 1,083 (APC: +7.96%) and female deaths from 210 to 613 (APC: +5.23%), indicating a steeper rise among men. Mortality increased most in small metro (+7.85%) and non-core rural areas (+7.76%), revealing geographic disparities. Among racial groups, Whites experienced a higher APC (+6.97%) compared to Black or African American individuals (+5.13%). Deaths among Hispanic individuals showed an APC of +6.79%. Age-stratified analysis identified the highest APCs in those aged 55–64 (+8.55%) and 85+ (+7.59%), underscoring growing mortality in both midlife and the oldest age groups.
Conclusion
Mortality due to KC with HD as a contributing condition has risen substantially, particularly among males, rural populations, Whites, and older adults. These findings underscore the need for integrated cardio-oncology strategies targeting high-risk, underserved groups.