Abstract: SA-PO0211
Kidney Failure and Cancer: A 25-Year CDC WONDER Analysis
Session Information
- Onconephrology: MGRS, HSCT, Electrolytes, RCC, and More
November 08, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Onconephrology
- 1700 Onconephrology
Authors
- Hassan, Furqan, Nishtar Medical University, Multan, Punjab, Pakistan
- Amjad, Amyla, University of North Dakota, Grand Forks, North Dakota, United States
- Jain, Samiksha, Guntur Medical College, Guntur, AP, India
- Zaman, Maham, Quaid-e-Azam Medical College, Bahawalpur, Punjab, Pakistan
- Mannan, Muhammad Shaheer, Marshfield Clinic Health System Inc, Marshfield, Wisconsin, United States
- Qureshi, Jumshaid Ahmed, Nishtar Medical University, Multan, Punjab, Pakistan
Background
Renal failure (RF) and malignant cancers are among the leading causes of death in the United States. Both conditions are connected in a complex bidirectional way. This study examines mortality trends and disparities related to these conditions over 25 years (1999-2023), focusing on demographic and regional disparities.
Methods
Mortality data from CDC WONDER was analyzed for individuals aged 25 and over, using relevant ICD-10 codes. Crude mortality rates (CMRs) and age-adjusted mortality rates (AAMRs) per 100,000 were calculated. Joinpoint regression estimated annual percentage changes (APCs), with significance defined as 95% CI excluding zero (p < 0.05).
Results
A total of 748,961 deaths occurred from RF and malignant cancers, with males accounting for 60% deaths. Overall, the AAMR started from 13.38 and ended at 15.37, rising significantly from 2015 (11.28) till 2023 [APC: 5.03 (95% CI, 3.24 – 6.86)]. Every stratum also saw a significant rise in AAMR and CMR in the latter years. Males had a higher average AAMR (19.51) than females (9.45), but both saw an increase in AAMR from 2015 to 2023, in which females took the lead [APC: 6.09 (95% CI, 4.22 – 8.00)], followed by males [APC: 4.22]. Non-Hispanic (NH) Whites had the greatest number of deaths (74.3%), followed by the NH Blacks (15.6%). NH Blacks had the highest average AAMR (22.97), followed by NH American Indians (13.85) and NH Whites (12.70). NH Whites had the steepest rise in AAMR from 2017 to 2023 [APC: 7.48 (95% CI, 4.43 - 10.62)], followed by NH American Indians [APC: 6.45]. Individuals in 75-84 years age group had most deaths (31.5%), whereas those aged 85+ had the highest average CMR (122.34). Young and middle-aged adults saw a higher rise in CMR, with 35-44 age group having the highest rise from 2019 – 2023 [APC: 14.64 (95% CI, 8.00-21.70)]. Midwest had the highest average AAMR (14), but South saw the most deaths (35.9%) and the highest rise in AAMR from 2016 till 2023 [APC: 6.62 (95% CI, 4.72 – 8.56)]. Kentucky had the greatest rise in its AAMR, going from 12.59 to 24.78, while District of Columbia had the greatest decline, going from 27.05 to 21.10.
Conclusion
Our study reveals significant mortality disparities with males, NH Blacks and 85+ individuals disproportionately affected. Geographic disparities and the recent rise in mortality highlight the need for targeted interventions.