Abstract: FR-PO0257
Greater Progression of Coronary Artery Calcification in Patients Undergoing Hemodialysis and Peritoneal Dialysis Compared with Patients with Nondialysis-Dependent CKD
Session Information
- Bone and Mineral Metabolism: Clinical Epidemiology and Outcomes
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Bone and Mineral Metabolism
- 502 Bone and Mineral Metabolism: Clinical
Authors
- Tsuruya, Kazuhiko, Nara Kenritsu Ika Daigaku, Kashihara, Nara Prefecture, Japan
- Yoshida, Hisako, Osaka Koritsu Daigaku Igakubu Daigakuin Igaku Kenkyuka, Osaka, Osaka Prefecture, Japan
- Yamada, Shunsuke, Kyushu Daigaku, Fukuoka, Fukuoka Prefecture, Japan
- Nakano, Toshiaki, Kyushu Daigaku, Fukuoka, Fukuoka Prefecture, Japan
Background
Vascular calcification is a major complication in chronic kidney disease (CKD). However, few studies have directly compared the progression of vascular calcification between patients with non-dialysis CKD (ND) and those receiving maintenance hemodialysis (HD) or peritoneal dialysis (PD). This study aimed to assess and compare the progression of coronary artery calcification (CAC) over a two-year period among ND, HD, and PD patients.
Methods
Among 258 (106 ND-CKD, 78 HD, and 74 PD) patients who underwent multi-detector computed tomography (MDCT), 187 (92 ND, 50 HD, and 45 PD) completed a follow-up MDCT 2 years later and were included in the analysis. Changes in CAC scores between the first and second scans were assessed. The annual change rate of CAC was calculated as: (365 × Δ square root-transformed CAC score) / (interval days between scans). CAC progression was defined as an increase in the square root-transformed CAC score of >2.5.
Results
The median (interquartile range) change in CAC score over two years and the annual change rate were significantly higher in HD patients [114 (35–765), 2.65 (1.03–5.56)] and PD patients [189 (42–699), 3.84 (1.45–8.06)] compared to ND [12 (0–81), 0.66 (0–1.66)]. The proportion of patients with CAC progression was also significantly higher in HD (72.0%) and PD (82.2%) groups than in the ND group (37.0%) (P <0.001). Multiple linear regression analysis showed that the annual change rate of CAC was significantly greater in HD and PD patients than in ND patients, even after adjusting for covariates including CKD-mineral bone disorders-related variables. No significant difference was observed between HD and PD.
Conclusion
Dialysis patients exhibited significantly more rapid progression of CAC than ND patients. The similar progression rates between HD and PD suggest that the uremic milieu, rather than dialysis modality, may play a dominant role in accelerating vascular calcification.