Abstract: TH-PO0348
Kidney Hemodynamic Function in Historic vs. Contemporary Patients with Type 1 Diabetes
Session Information
- Diabetic Kidney Disease: From Early Biomarkers to Novel Therapeutic Targets
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Diabetic Kidney Disease
- 702 Diabetic Kidney Disease: Clinical
Authors
- Kendrick, Jessica B., University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, United States
- Furgeson, Seth B., University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, United States
- Dixon, Angelina Magreni, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, United States
- You, Zhiying, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, United States
- Cherney, David, Toronto General Hospital, Toronto, Ontario, Canada
- Perkins, Bruce A., University of Toronto, Toronto, Ontario, Canada
- Bjornstad, Petter, University of Washington School of Medicine, Seattle, Washington, United States
Background
Advances in insulin technology have led to better glycemic control in patients with type 1 diabetes (T1D), but whether renal hemodynamic function has changed over time with advances in insulin technology in T1D is unknown.
Methods
We measured renal hemodynamic function in 23 patients with long-standing T1D from an ongoing clinical trial and compared findings to those from older adults with T1D from the Canadian Study of Longevity in Type 1 Diabetes (Lytvyn et al. AJKD 2019). Glomerular filtration rate (GFR) was measured using iohexol clearance, effective renal plasma flow (RPF) measured using para-aminohippurate clearance, while intraglomerular pressure (PGLO), renal vascular resistance (RVR), efferent arteriole resistance (RE), and afferent arteriolar resistance (RA) estimated using the Gomez equations.
Results
Participants from the contemporary cohort were slightly younger and more likely to be male than the historic cohort (Table). HbA1c trended towards being lower in the contemporary cohort but it did not reach statistical significance. GFR, RPF, RBF, and PGLO were significantly greater in the contemporary vs. historic cohort. In contrast, FF, RVR, RE, and RA were significantly lower in the contemporary cohort. There were no differences in systolic blood pressure or mean arterial pressure between the groups.
Conclusion
T1D patients from the contemporary cohort had significantly less renal vasoconstriction and intraglomerular pressure than patients from the historic cohort.
| Parameter | Contemporary Cohort (N=23) | Historic Cohort (N=66) | P-value |
| Demographic and Clinical Characteristics | |||
| Age, years | 60 ± 15 | 66 ± 8 | 0.01 |
| Male, N (%) | 17 (73.9) | 30 (45) | <0.0001 |
| BMI, kg/m2 | 28.1 ± 6.3 | 26.6 ± 3.9 | 0.29 |
| HbA1C, % | 7.0 ± 0.8 | 7.4 ± 0.8 | 0.07 |
| Renal Hemodynamic Function | |||
| RPF (ml/min) | 586 ± 112 | 447 ± 101 | <0.0001 |
| GFR (ml/min) | 107 ± 17 | 103 ± 17 | <0.0001 |
| Filtration Fraction | 0.19 ± 0.03 | 0.24 ± 0.04 | <0.0001 |
| RBF (L/min) | 1025 ± 251 | 689 ± 166 | <0.0001 |
| RVR (mm Hg/L/min) | 0.09 ± 0.02 | 0.14 ± 0.04 | <0.0001 |
| Intraglomerular Hemodynamic Parameters | |||
| PGLO, mm Hg | 54.3 ± 4.2 | 51.4 ± 4.3 | 0.006 |
| R E, dyne-s-cm-5 | 2,954 ± 878 | 4,546 ± 1714 | <0.0001 |
| RE, dyne-s-cm-5 | 1,586 ± 311 | 2,403 ± 544 | <0.0001 |
Mean (SD) unless otherwise specified
Funding
- Private Foundation Support