Kidney Week

Abstract: TH-PO1058

Association of Combining Obesity with Systemic Inflammatory Response Index and Microalbuminuria in the US Population: NHANES, 2017-2020

Session Information

• CKD: Epidemiology, Risk Factors, and Other Conditions
  November 06, 2025 | Location: Exhibit Hall, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Bunyawannukul, Issaree, Division of Nephrology, Hypertension and Kidney Transplantation, Department of Medicine, University of California Irvine, Orange, California, United States

Issaree Bunyawannukul, MD

• Kookanok, Chutawat, Interfaith Medical Center, New York, New York, United States

Chutawat Kookanok, MD

• Mohpichai, Nopavit, Division of Nephrology, Hypertension and Kidney Transplantation, Department of Medicine, University of California Irvine, Orange, United States

Nopavit Mohpichai

• Wongmat, Napat, Division of Nephrology, Hypertension and Kidney Transplantation, Department of Medicine, University of California Irvine, Orange, California, United States

Napat Wongmat, MD

• Yongkiatkan, Panchanit, Division of Nephrology, Hypertension and Kidney Transplantation, Department of Medicine, University of California Irvine, Orange, California, United States

Panchanit Yongkiatkan, MD

• Wareesawetsuwan, Nicha, Division of Nephrology, Hypertension and Kidney Transplantation, Department of Medicine, University of California Irvine, Orange, California, United States

Nicha Wareesawetsuwan, MD

• Puyati, Weerinth, Division of Nephrology, Hypertension and Kidney Transplantation, Department of Medicine, University of California Irvine, Orange, California, United States

Weerinth Puyati, MD

• Poochanasri, Methavee, Phramongkutklao Hospital, Bangkok, Thailand

Methavee Poochanasri, MD

• Kantachuvesiri, Surasak, Excellent Center for Organ Transplantation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Surasak Kantachuvesiri, MD

• Tantisattamo, Ekamol, Division of Nephrology, Hypertension and Kidney Transplantation, Department of Medicine, University of California Irvine, Orange, United States

Ekamol Tantisattamo, MD, MPH, FASN

Background

Obesity and inflammation are known to contribute to kidney damage. While the Systemic Inflammatory Response Index (SIRI) has prognostic value in CVD, its role in kidney injury is less clear. Given the link between obesity and inflammation, combining SIRI with obesity measures may improve proteinuria risk stratification. This study explores whether this combination enhances prediction and early identification of proteinuria.

Methods

We analyzed data from 6,519 adults (NHANES 2017–2020). Microalbuminuria (MA) was defined as a urine albumin-creatinine ratio greater than 30 mg/L. SIRI was calculated as (neutrophils × monocytes) / lymphocytes. ROC analysis identified SIRI × BMI × WHR as the optimal predictor of proteinuria. Its association with microalbuminuria was evaluated using multivariable logistic regression and subgroup analyses.

Results

This study included a total of 6,519 participants, of whom 784 (12%) had MA. The ability of the the index to predict the outcome is compared and illustrated in Fig. 1A with subgroups in smoking and diabetes focusing on SIRI × BMI × WHR in Fig 1B. Interaction. The forest plot reveals significant association between inflammatory and obesity index with further amplified by smoking and diabetes status Fig.2.

Conclusion

The index demonstrated an association with MA, with its being more pronounced in individuals with diabetes and smoking. Given its cost-effectiveness, this index could serve as a valuable tool for nationwide kidney injury screening and early risk assessment.

Fig 1:ROC curve analysis

Fig 2:Forest plot of interaction

Digital Object Identifier (DOI)

• doi: 10.1681/ASN.20257a065zdm