Abstract: FR-PO0406
Volume Overload Assessed by Vector Impedance Analysis Is Associated with Poor Physical Function in Hemodialysis
Session Information
- Dialysis: Measuring and Managing Symptoms and Syndromes
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Martin Alemañy, Geovana, University of Arizona, School of Nutritional Science and Wellness, Tucson, Arizona, United States
- Perez-Navarro, L. Monserrat, Hospital General de Mexico Dr Eduardo Liceaga, Mexico City, CDMX, Mexico
- Colin-Ramirez, Eloisa, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Departamento de Vigilancia Epidemiológica, Mexico City, Mexico
- Ramos-Acevedo, Samuel, McMaster University, Faculty of Health Sciences, Department of Medicine, Hamilton, Ontario, Canada
- Hasankhani, Milad, University of Arizona, School of Nutritional Science and Wellness, Tucson, Arizona, United States
- Valdez-Ortiz, Rafael, Hospital General de Mexico Dr Eduardo Liceaga, Mexico City, CDMX, Mexico
- Espinosa-Cuevas, Angeles, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Departamento de Vigilancia Epidemiológica, Mexico City, Mexico
- Wilund, Kenneth Robert, University of Arizona, School of Nutritional Science and Wellness, Tucson, Arizona, United States
Background
Loss of skeletal muscle mass in chronic kidney disease (CKD) is linked to reduced physical function (PF). While this is well established, the role of volume overload (VO) common in hemodialysis (HD) patients remains underexplored.
Methods
A total of 52 HD patients were included. MS was assessed using hand dynamometry. PF was measured using the Short Physical Performance Battery (SPPB), with "low PF" defined as a score ≤ 8. BIVA was graphed according to PF and MS classification as normal or reduced. The comparison of BIVA between groups was performed using Hotelling's T test. In addition, multivariate logistic regression (MLR) was used to explore the association between VO, MS, and PF.
Results
BIVA graphs showed that patients with reduced PF were outside the 95th percentile, indicating VO, while those with normal PF had adequate hydration status (p=0.000). Only men with reduced MS had VO (p=0.003) (Figure 1). In Model 1 of the MLR, VO, age, and MS were associated with low PF; however, in Model 2, MS and diabetes remained significant predictors of low PF, while VO lost statistical significance (Table 1).
Conclusion
HD patients with reduced PF and MS exhibited higher VO. Although VO is associated with worse PF.
Table 1. Multivariate Logistic Regression Model: Association Between Volume Overload, Physical Function, and Muscle Strength in Hemodialysis Patients
| Variables | Poor Physical Function (SPPB < 8) | ||
| Model 1 | OR | IC 95 % | |
| Sex (m o f) | 0.398 | 0.039 | 4.060 |
| Age (years) | 0.917 | 0.847 | 0.993 |
| VO (yes/no) | 0.086 | 0.007 | 0.990 |
| Muscle strength (good/poor) | 1.292 | 1.045 | 1.597 |
| Model 2 | OR | IC95% | |
| Sex (m o f) | 0.478 | 0.027 | 8.607 |
| Age (years) | 0.939 | 0.846 | 1.042 |
| VO (yes/no) | 0.258 | 0.015 | 4.533 |
| Muscle strength (good/poor) | 1.703 | 1.131 | 2.565 |
| Diabetes (yes/no) | 0.007 | 0.000 | 0.460 |
Funding
- Private Foundation Support