Abstract: SA-PO0658
Unearthing the Silent Threat: Three-Decade Global Trends in Pediatric Kidney Cancer (<20 Years) Across 204 Nations, 1990-2021
Session Information
- Pediatric Nephrology: Transplantation, Hypertension, AKI, Genetics, and Developmental Diseases
November 08, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Pediatric Nephrology
- 1900 Pediatric Nephrology
Authors
- Patel, Zeel, AUC School of Medicine, Cupecoy, Sint Maarten (Dutch part)
- Bhatt, Manas, Government Medical College, Bhavnagar, India
- Shah, Dhruvil K., Western Reserve Health Education, Warren, Ohio, United States
- Ashar, Mili H, Rural Medical College, Loni, Maharashtra (Pravara Institute of Medical Sciences), Maharashtra, India
- Patel, Kevin M, Gujarat Adani Institute of Medical Sciences, Bhuj, India
- Patel, Juhi, Gujarat Medical Education and Research Society Medical College & Hospital Valsad, Valsad, India
- Amin, Vishrant, Gujarat Medical Education and Research Society Medical College & Hospital Valsad, Valsad, India
- Desai, Hardik Dineshbhai, Gujarat Adani Institute of Medical Sciences, Bhuj, India
Background
Pediatric kidney cancer (KC), though rare, poses significant clinical challenges. Wilms tumor is the predominant subtype in this age group, yet global epidemiological patterns remain poorly characterized. Understanding long-term trends is essential to inform early diagnosis, equitable care, and pediatric cancer control strategies worldwide.
Methods
The burden of KC in individuals aged <20 years was assessed across 204 countries from 1990 to 2021 using standardized modeling from the Global Burden of Disease (GBD) Study 2021. Age-standardized rates of incidence, prevalence, mortality, and disability-adjusted life years (DALYs) were analyzed.
Results
Total percentage change (TPC) in prevalence was highest in Sub-Saharan Africa (+136%), followed by South Asia (+42%) and North Africa and the Middle East (+4%). By sociodemographic index (SDI), the largest increases were observed in low SDI (+120%) and low-middle SDI (+46%) regions, while others showed reductions. The greatest age-specific increases occurred in the 10–14 years (+44%) and 15–19 years (+39%) groups. Males exhibited a higher burden than females, with incidence rising by 14% in males but declining by 20% in females. Mortality declined more substantially in females (−42%) than in males (−8%).
Conclusion
Over the past three decades, pediatric KC has shown rising prevalence in low-resource and adolescent populations, with widening disparities across SDI levels, age groups, and sex. These trends underscore the urgent need for strengthened pediatric oncology systems, early detection programs, and targeted interventions in vulnerable regions.