Abstract: PUB277
Biomarkers in Cardiovascular Risk Stratification in Patients with Nephropathy
Session Information
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Andracchio, Ludovica, Azienda Ospedaliera San Camillo Forlanini, Rome, Lazio, Italy
- Iafisco, Alma, Azienda Ospedaliera San Camillo Forlanini, Rome, Lazio, Italy
- Luciani, Remo, Azienda Ospedaliera San Camillo Forlanini, Rome, Lazio, Italy
- De Paolis, Paolo, Azienda Ospedaliera San Camillo Forlanini, Rome, Lazio, Italy
Group or Team Name
- Nephrology Dialysis and Transplant Kidney AO San Camillo Forlanini Roma.
Background
Cardiovascular disease is the leading cause of death in nephropathic patients. Risk factors such as systemic inflammation, immunosuppression and diet are common in kidney patients; they modify body composition, resulting in increased deposition of visceral fat, a known CVD risk factor. The use of different biomarkers, such as: anthropometric parameters, bioimpedance and echocardiography are useful in the stratification of CV risk in four populations of kidney patients.
Methods
A prospective, cross-sectional study was conducted, enrolling, from January to March 2025, 38 patients of whom: 9 kidney transplant recipients, 9 pre-dialysis , 9 hemodialysis and 9 peritoneal dialysis patients.
Each patient underwent:
-anthropometric data: height, weight and BMI,
-bioimpedance analysis,
- two-dimensional echocardiography with evaluation of epicardial fat thickness.
Results
We observed in the transplant group a higher prevalence of metabolically obese (NMOW) patients with a mean body fat percentage (BF%) of 35% ( Fig. 1)and a higher epicardial fat thickness, with a mean value of 45 mm (Fig. 2).
Conclusion
Biomarkers have provided a decisive contribution in defining cardiovascular risk. Kidney transplant patients present a higher cardiovascular risk, which could be attributable to immunosuppressive therapy.