Abstract: FR-PO0884
Prevalence and Risk Factors for AKI in Patients with Nephrotic Syndrome and Nephrotic-Range Proteinuria
Session Information
- Glomerular Outcomes: From Proteinuria to Prognosis
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Dominguez Franco, Miguel Angel, Hospital General de Mexico Dr Eduardo Liceaga, Mexico City, CDMX, Mexico
- Soto, Virgilia, Instituto Nacional de Cardiologia Ignacio Chavez, State of Mexico, Méx., Mexico
- Perez-Navarro, L. Monserrat, Hospital General de Mexico Dr Eduardo Liceaga, Mexico City, CDMX, Mexico
- Cordoba Hurtado, Angela Maria, Hospital General de Mexico Dr Eduardo Liceaga, Mexico City, CDMX, Mexico
Background
Acute kidney injury (AKI) is a common and serious complication in patients with nephrotic syndrome (NS) and nephrotic range proteinuria, often leading to CKD and ESKD. Data on prevalence and AKI predictors are limited, especially in Latin America Population.
Methods
Retrospective cohort study of adult patients with NS and nephrotic range proteinuria at General Hospital of Mexico (2012-2024). Clinical, biochemical, and histopathological variables were analyzed. Univariate analysis and logistic regression were used to identify independent risk factors. A p-value<0.05 was considered statistically significant.
Results
A total of 152 adult patients were analyzed. Average age was 42.7 ± 17.3, the prevalence of AKI was 63.8%, 50.5% had KDIGO 1, 27,8% KDIGO 2, and 21.6% KDIGO 3. NS was present in 70,4%, and 29,6% had nephrotic range proteinuria. The most common primary GN was FSGS; and the secondary more frequent was Diabetic nephropathy. The average UPCR was 9.14 (3.5-32.56) g/g. In the logistic regression the following variables were associated with AKI. Age OR 2.39 (95%CI 1.22-4,72, p=0,01), and the histological variables the TIN was associated with AKI with OR 3.57 (95%CI 1.16-11.04, p=0,02), and in the histopathological diagnosis Diabetic nephropathy was associated with AKI OR 3,87 (95%CI 1,58-9,47, p=0,003).
Conclusion
AKI occurred in nearly 2/3 of patients with NS or nephrotic range proteinuria. Higher proteinuria, older age, TIN and diabetic nephropathy were independent predictors of AKI. These findings emphasize the importance of early detection and close monitoring in high-risk glomerular patterns.