Abstract: FR-PO0079
Mortality Trends from Kidney Failure and Sepsis
Session Information
- AKI: Epidemiology, Risk Factors, and Prevention
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 101 AKI: Epidemiology, Risk Factors, and Prevention
Authors
- Hassan, Furqan, Nishtar Medical University, Multan, Punjab, Pakistan
- Amjad, Amyla, University of North Dakota, Grand Forks, North Dakota, United States
- Zaman, Maham, Quaid-e-Azam Medical College, Bahawalpur, Punjab, Pakistan
- Jain, Samiksha, Guntur Medical College, Guntur, AP, India
- Mannan, Muhammad Shaheer, Marshfield Clinic Health System Inc, Marshfield, Wisconsin, United States
- Qureshi, Jumshaid Ahmed, Nishtar Medical University, Multan, Punjab, Pakistan
Background
Sepsis is a life-threatening condition and a leading contributor to in-hospital mortality. Renal failure (RF), a common complication in sepsis, exacerbates outcomes and increases risk of death. While both conditions are well-documented individually, our study will be the one examining trends in mortality, where both these conditions co-occur, over a 25-year period (1999-2023).
Methods
Mortality data from CDC WONDER was analyzed for individuals aged 25 and over, using relevant ICD-10 codes. Crude mortality rates (CMRs) and age-adjusted mortality rates (AAMRs) per 100,000 were calculated. Joinpoint regression estimated annual and average annual percentage change (APC & AAPC), with significance defined as 95% CI excluding zero (p < 0.05).
Results
A total of 903,257 deaths occurred from sepsis and RF, with AAMR starting from 14.44 and ending at 19.50 (AAPC: 1.83 [95% CI, 0.27 – 3.40]), with the highest increase occurring from 2018-2023 (APC: 9.83 [95% CI, 4.78 – 15.13]). Males accounted for 51.49% of deaths with a higher AAMR trend and an average AAMR of 19.43 as compared to females (13.80). Non-Hispanic (NH) Whites had the most deaths (67.52%), with AAMR starting from 11.58 and going to 18.25 (AAPC: 2.55). NH Blacks had the highest AAMR average (33.29), followed by NH American Indians (24.77). NH Blacks saw a significant decline from 2005 (39.71) till 2018 (24.31) [APC: -4.33] but remained the highest trending AAMR till 2020. NH American Indians then took over, due to their AAMR rising from 2018 (20.93) till 2021 (36.68) (APC: 22.10). Individuals in 75-84 year age group saw the most deaths (28.30%). Individuals of 85+ years had the highest CMR average (138.57) but the greatest rise in CMR was seen in age groups of 35-44 years (APC: 27.36) and 25-34 years (APC: 24.40). South had most deaths (42.06%) and the highest average AAMR (18.45). Northeast had an overall declining AAMR (AAPC: -1.00), while the West had the steepest increase (AAPC: 1.40). From 1999-2023, Kentucky’s AAMR rose from 15.00 to 41.80, whereas District of Columbia’s dropped from 48.80 to 22.60.
Conclusion
Although the mortality burden is high in males, NH Blacks and older adults, the recent rise in mortality trends highlighted that NH American Indians, NH Whites and young adults are disproportionately affected, highlighting the need for targeted interventions.