Kidney Week

Abstract: PUB083

70 Years of Type 1 Diabetes Without Proteinuria, Neuropathy, or Retinopathy: Lessons from an Exceptional Patient

Session Information

• Publication Only

Category: Diabetic Kidney Disease

• 702 Diabetic Kidney Disease: Clinical

Authors

• Mariani, Ilaria, Centre Hospitalier du Mans, Le Mans, Pays de la Loire, France

Ilaria Mariani

• Carta, Simona, Centre Hospitalier du Mans, Le Mans, Pays de la Loire, France

Simona Carta, MD

• Porcu, Clara Valentina, Centre Hospitalier du Mans, Le Mans, Pays de la Loire, France

Clara Valentina Porcu

• Gianferrari, Matteo, Centre Hospitalier du Mans, Le Mans, Pays de la Loire, France

Matteo Gianferrari, MS

• Chatrenet, Antoine, Centre Hospitalier du Mans, Le Mans, Pays de la Loire, France

Antoine Chatrenet, PhD

• Fois, Antioco, Centre Hospitalier du Mans, Le Mans, Pays de la Loire, France

Antioco Fois, MD

• Torreggiani, Massimo, Centre Hospitalier du Mans, Le Mans, Pays de la Loire, France

Massimo Torreggiani, MD, PhD

• Piccoli, Giorgina B., Centre Hospitalier du Mans, Le Mans, Pays de la Loire, France

Giorgina B. Piccoli, MD

Introduction

Though isolated cases cannot define standards, they may offer valuable clinical insights. Despite therapeutic advances, individuals with type 1 diabetes from earlier eras rarely avoid complications. A 70-year survivor without end-organ damage is therefore remarkable.

Case Description

A 76-year-old retired computer scientist, diagnosed at age 6 with classic polyuria–polydipsia, was referred for moderate renal impairment. He never had diabetic ketoacidosis but experienced frequent hypoglycemia.
He adapted to major changes in insulin therapy—from once-daily injections and glycosuria-based monitoring to current individualized regimens.
Since childhood, he has maintained regular, vigorous physical activity, still exercising 40–60 minutes daily and tending his large garden.
He has practiced functional insulin therapy for over 40 years, with consistent meals in the morning and afternoon, and flexible evening intake. Current treatment includes insulin lispro per protocol and dapagliflozin.
He presented in excellent condition despite moderate renal impairment (creatinine 165 µmol/L; eGFR 34 mL/min/1.73 m2, mGFR 50.4 ml/min/1.73 m2), with normal BMI, well-controlled hypertension (hydrochlorothiazide and potassium losartan), preserved muscle mass, and no complaints. Proteinuria was minimal (0.09 g/24h); no electrolyte or acid–base imbalances were found. CT showed normal kidney size and diffuse arterial calcifications. No retinopathy was detected; only mild reduction in vibration sense was noted. Handgrip strength exceeded age norms.
Asked about his success, he cited understanding, empowerment, sport, and caring, competent physicians.

Discussion

This case highlights how lifelong physical activity, self-management, and adherence to therapy can prevent or delay diabetes complications. It reinforces the value of education, motivation, and long-term, empathetic medical support in chronic care.

Digital Object Identifier (DOI)

• doi: 10.1681/ASN.20251624cw2v