Basic/Clinical Science Session
Genetic Insights into Tubular Function: Unlocking the Mysteries of Chronic Electrolyte Disorders
November 06, 2025 | 02:00 PM - 04:00 PM
Location: Room 320A, Convention Center
Session Description
The kidney tubules are vital for maintaining electrolyte homeostasis, and their dysfunction can lead to chronic electrolyte disturbances. Recent advances in genetics have identified a host of inherited tubulopathies that provide critical insights into tubular function. This session explores how studying genetic disorders across the spectrum of electrolyte handling, from salt-wasting to salt-retaining conditions such as Gitelman and Gordon syndromes, magnesium-wasting tubulopathies, and stone-forming conditions, informs understanding of tubular physiology and guides personalized therapeutic approaches.
Learning Objective(s)
- Summarize recent genetic discoveries in tubulopathies and their implications for tubular function
- Describe how genetic insights are reshaping the understanding of the spectrum of sodium chloride handling disorders, from Gitelman to Gordon syndromes
- Explain the role of genetic pathogenic variants in stone-formation and magnesium-wasting conditions
- Identify opportunities for translating genetic knowledge into clinical care for chronic electrolyte disturbances
Learning Pathway(s)
- Fluid‚ Electrolyte‚ and Acid-Base Disorders
- Genetic Diseases and Development
Moderators
Presentations
- Spectrum of Sodium Chloride Cotransporter Regulation: From Gitelman to Gordon Syndromes
02:00 PM - 02:30 PM
- Magnesium Wasting: A Window into Tubular Magnesium Handling
02:30 PM - 03:00 PM
- Stone Formers and Genetic Links: Calcium Channels Under the Spotlight
03:00 PM - 03:30 PM
- From Bench to Bedside: Translating Tubular Genetics into Clinical Care
03:30 PM - 04:00 PM