Basic/Clinical Science Session
Aldosterone-Dependent and -Independent Mechanisms in Sodium Transport and Hypertension
November 08, 2025 | 02:00 PM - 04:00 PM
Location: Room 372A, Convention Center
Session Description
This session focuses on the molecular and physiological mechanisms by which sodium transporters in the kidneys are regulated under aldosterone-dependent and -independent pathways. Experts discuss how aldosterone-driven processes affect kidney function and BP regulation, alongside nontraditional modulators of sodium transport. The session also explores salt-sensitive hypertension, inflammation, and kidney injury, providing a comprehensive understanding of their role in disease progression and potential therapeutic targets.
Learning Objective(s)
- Describe the mechanisms by which aldosterone modulates sodium transport in the kidneys, contributing to hypertension and kidney damage
- Explain how regulators such as plasmin, angiotensin 2, and bile acids influence sodium transporter activity and their implications for kidney health and hypertension
- Evaluate the interaction between inflammation, aldosterone-dependent pathways, and aldosterone-independent mechanisms in the context of salt-sensitive hypertension and kidney injury
Learning Pathway(s)
- Hypertension and Cardiorenal Disorders
- Fluid‚ Electrolyte‚ and Acid-Base Disorders
Moderators
Presentations
- Epithelial Sodium Channel Regulation Independent of Aldosterone
02:00 PM - 02:30 PM
- Immune Epithelial Sodium Channels and Salt-Sensitive Hypertension
02:30 PM - 03:00 PM
- Primary Aldosteronism: An Underdiagnosed Cause of High BP
03:00 PM - 03:30 PM
- Aldosterone-Dependent and -Independent Regulation of Epithelial Sodium Channels in the Kidneys
03:30 PM - 04:00 PM