Basic/Clinical Science Session
Sex and Kidney Metabolism: A New Frontier to Better Understand and Treat Kidney Diseases
November 08, 2025 | 02:00 PM - 04:00 PM
Location: Room 320A, Convention Center
Session Description
Sex dimorphism significantly affects kidney diseases, with men facing higher risks of diabetic kidney disease (DKD) and more severe ischemia reperfusion injury, while women lose protection after menopause and are more prone to allograft rejection. Despite these variances, women are underrepresented in clinical and preclinical studies. This session discusses recent studies showing key differences in male and female kidney cell metabolism and stresses the need to consider sex as a crucial biological variable in future studies, as supported by genome-wide association study findings on X-chromosome genes linked to kidney traits.
Learning Objective(s)
- Explain the importance of disaggregation of sex-based data in clinical and preclinical studies
- Evaluate the impact of sex hormones and sex chromosomes on kidney cell metabolism in DKD and ischemia reperfusion injury
- Identify sex chromosome-encoded genetic loci associated with kidney traits
- Describe animal models used to decipher the role of sex chromosomes and sex hormones in kidney diseases
Learning Pathway(s)
- CKD Non-Dialysis
Moderators
Presentations
- Sex-Specific Manipulation of Kidney Metabolism: A Novel Therapeutic Opportunity in DKD?
02:00 PM - 02:30 PM
- What Do Multi-Trait Genetic Analyses Tell Us About Sex Chromosomes and the Kidneys?
02:30 PM - 03:00 PM
- How Does Sex Influence Metabolism and Kidney Repair in Ischemia Reperfusion Injury?
03:00 PM - 03:30 PM
- What Do Animal Models Tell Us About the Role of Sex Chromosomes and Sex Hormones in Kidney Diseases?
03:30 PM - 04:00 PM