Kidney Week

Basic/Clinical Science Session

Emerging Insights on the Evaluation of Kidney Stone Risk

November 07, 2025 | 02:00 PM - 04:00 PM

Location: Room 370A, Convention Center

Session Description

The pathogenesis of kidney stones is complex, involving both genetic and environmental risk factors that mediate the urinary composition of key lithogenic molecules. When intrarenal crystals form, the biologic response, including those by macrophages, appears to be pubertal in determining their ultimate fate. Rare monogenic causes of kidney stones are especially important to recognize since they can lead to nephrocalcinosis and kidney failure, and targeted molecular therapies are increasingly available. This session provides a clinically relevant update on these genetic, environmental, and biochemical risk factors for kidney stone formation.

Learning Objective(s)

• Identify monogenic causes of nephrocalcinosis and nephrolithiasis
• Explain how 24-hour urine chemistry can inform the evaluation of patients with kidney stones
• Describe various environmental and pharmaceutical exposures that increase the risk of kidney stone formation

Learning Pathway(s)

• Bones‚ Stones‚ and Mineral Metabolism
• Genetic Diseases and Development

Moderators

• John C. Lieske, MD, FASN
• Lama Nazzal, MD, MS

Presentations

• Don't Miss the Needle in a Haystack: Monogenic Causes of Nephrolithiasis and Nephrocalcinosis
  02:00 PM - 02:30 PM
  
  • Felix Knauf, MD

Don't Miss the Needle in a Haystack: Monogenic Causes of Nephrolithiasis and Nephrocalcinosis

November 07, 2025 | 02:00 PM - 02:30 PM

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• Sodium-Phosphate Transporters and Kidney Stone Disease: Rare or Common Cause?
  02:30 PM - 03:00 PM
  
  • Alexander R. Chang, MD, MS

Sodium-Phosphate Transporters and Kidney Stone Disease: Rare or Common Cause?

November 07, 2025 | 02:30 PM - 03:00 PM

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• Insights from the 24-Hour Urine Chemistry Panel
  03:00 PM - 03:30 PM
  
  • Megan Prochaska, MD, MPH

Insights from the 24-Hour Urine Chemistry Panel

November 07, 2025 | 03:00 PM - 03:30 PM

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• Iatrogenic and Environmental Causes of Kidney Stone Disease
  03:30 PM - 04:00 PM
  
  • Emmanuel Letavernier, MD, PhD

Iatrogenic and Environmental Causes of Kidney Stone Disease

November 07, 2025 | 03:30 PM - 04:00 PM

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