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Abstract: TH-PO1041

The Global, Regional, and National State of CKD Epidemiology from 1990 to 2016: An analysis of the Global Burden of Disease Study

Session Information

Category: CKD (Non-Dialysis)

  • 1901 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Xie, Yan, VA Saint Louis Health Care System, Saint Louis, Missouri, United States
  • Bowe, Benjamin Charles, Research and Development Service, Veterans Affairs St Louis Health Care System, St. Louis, Missouri, United States
  • Xian, Hong, Saint Louis University College for Public Health & Social Justice, St. Louis, Missouri, United States
  • Yan, Yan, Washington University Medical School, Saint Louis, Missouri, United States
  • Li, Tingting, Washington University in St. Louis, Saint Louis, Missouri, United States
  • Maddukuri, Geetha S., VA Saint Louis Health Care System, Saint Louis, Missouri, United States
  • Tsai, Cheng-You, Saint Louis University College for Public Health & Social Justice, St. Louis, Missouri, United States
  • Floyd, Tasheia A., VA Saint Louis Health Care System, Saint Louis, Missouri, United States
  • Al-Aly, Ziyad, VA Saint Louis Health Care System, Saint Louis, Missouri, United States
Background

The last quarter century witnessed significant population growth, aging, and major changes in epidemiologic trends which may have shaped the state of chronic kidney disease (CKD) epidemiology. The GBD study provides a detailed epidemiologic assessment of 333 diseases and injuries and 84 risk factors by age and sex on a global scale and for 195 countries and territories.

Methods

Data collected from the GBD study will be used to describe the change in burden of CKD from 1990 to 2016. In this work, we used the Global Burden of Disease (GBD) study methodologies to describe the change in burden of CKD including decomposition analysis to understand factors that drove change and frontier analysis that evaluate the relationship between burden of CKD and socio-demographic development.

Results

Globally, incidence of CKD increased by 88.76% , prevalence increased by 86.95% , death due to CKD increased by 98.02% , and DALYs increased by 62.21%. Measures of burden varied substantially by level of development and by geography. Decomposition analyses showed that the increase in CKD DALYs was driven by population growth and aging; globally and in most GBD regions, age-standardized DALYs rates decreased. More of the CKD burden (62.96%) was in low and lower-middle-income countries; there was an inverse relationship between age-standardized CKD DALYs rate and healthcare access and quality (r=-0.52). Frontier analyses showed significant opportunities for improvement at all levels of the development spectrum.

Conclusion

Our results demonstrate that the global toll of CKD is significant, rising, and unevenly distributed; it is primarily driven by demographic expansion and in some regions significant tide of diabetes epidemic. Opportunities exist to reduce CKD burden at all levels of development.

Funding

  • Veterans Affairs Support