Abstract: FR-PO688
Tissue Sodium Stores in Peritoneal Dialysis Patients
Session Information
- Dialysis: Peritoneal Dialysis - II
October 26, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 703 Dialysis: Peritoneal Dialysis
Authors
- Tintara, Supisara, Vanderbilt University School of Medicine, Nashville, Tennessee, United States
- Alsouqi, Aseel, Vanderbilt University Medical Center, Nashville, Tennessee, United States
- Deger, Serpil muge, Vanderbilt University Faculty of Medicine Department of Nephrology, Nashville, Tennessee, United States
- Bian, Aihua, Vanderbilt University, Nashville, Tennessee, United States
- Stewart, Thomas G., Vanderbilt University Medical Center, Nashville, Tennessee, United States
- Titze, Jens, Duke - National University of Singapore, Singapore, Singapore
- Ikizler, Talat Alp, Vanderbilt University Medical Center, Nashville, Tennessee, United States
Background
A remarkable amount of sodium (Na+) is stored in the tissue without commensurate water retention, particularly in the skin and muscle. Using 23Na-magnetic resonance imaging (MRI), elevated tissue Na+ content was found in hemodialysis patients. Peritoneal dialysis (PD) patients generally have higher residual kidney function than HD patients, yet the effectiveness of PD in tissue Na+ removal has not been evaluated.
Methods
We examined tissue Na+ levels in 10 PD patients. PD patients were matched with healthy controls by age, race, gender and body mass index (BMI). All study subjects underwent 23Na-MRI to quantify Na+ levels in lower leg muscle and skin.
Results
We studied 10 PD patients and 41 controls. PD patients had significantly higher skin and muscle Na+ levels compared to controls (figure 1). In PD subjects, skin Na+ level was inversely correlated to ultrafiltration volume, a marker of Na+ removal adequacy (figure 2).
Conclusion
Our data suggest that PD patients have elevated tissue Na+ stores. The mechanisms by which this abnormality develops and its consequences should be further examined.
Characteristics of the study population
Patients on PD (n=10) | Controls (n=41) | P value^ | |
Age (years) | 55 [48.8, 61.5] | 51 [45, 59] | 0.55 |
Male | 3 (30) | 23 (56.1) | 0.14 |
African American | 4 (40) | 23 (56.1) | 0.25 |
Caucasian | 5 (50) | 18 (43.9) | |
BMI (kg/m^2) | 23.6 [21.9, 17.9] | 27.6 [25.4, 31.4] | 0.07 |
Creatinine (mg/dL) | 10.3 [7.2, 13.3] | 0.9 [0.8, 1.1] | <0.001 |
Urine output (mL/day) | 100 [50, 520] |
Continuous variables are presented as median [interquartile range], categorical variables are presented as n (%).
Funding
- Commercial Support –