ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: FR-PO688

Tissue Sodium Stores in Peritoneal Dialysis Patients

Session Information

Category: Dialysis

  • 703 Dialysis: Peritoneal Dialysis

Authors

  • Tintara, Supisara, Vanderbilt University School of Medicine, Nashville, Tennessee, United States
  • Alsouqi, Aseel, Vanderbilt University Medical Center, Nashville, Tennessee, United States
  • Deger, Serpil muge, Vanderbilt University Faculty of Medicine Department of Nephrology, Nashville, Tennessee, United States
  • Bian, Aihua, Vanderbilt University, Nashville, Tennessee, United States
  • Stewart, Thomas G., Vanderbilt University Medical Center, Nashville, Tennessee, United States
  • Titze, Jens, Duke - National University of Singapore, Singapore, Singapore
  • Ikizler, Talat Alp, Vanderbilt University Medical Center, Nashville, Tennessee, United States
Background

A remarkable amount of sodium (Na+) is stored in the tissue without commensurate water retention, particularly in the skin and muscle. Using 23Na-magnetic resonance imaging (MRI), elevated tissue Na+ content was found in hemodialysis patients. Peritoneal dialysis (PD) patients generally have higher residual kidney function than HD patients, yet the effectiveness of PD in tissue Na+ removal has not been evaluated.

Methods

We examined tissue Na+ levels in 10 PD patients. PD patients were matched with healthy controls by age, race, gender and body mass index (BMI). All study subjects underwent 23Na-MRI to quantify Na+ levels in lower leg muscle and skin.

Results

We studied 10 PD patients and 41 controls. PD patients had significantly higher skin and muscle Na+ levels compared to controls (figure 1). In PD subjects, skin Na+ level was inversely correlated to ultrafiltration volume, a marker of Na+ removal adequacy (figure 2).

Conclusion

Our data suggest that PD patients have elevated tissue Na+ stores. The mechanisms by which this abnormality develops and its consequences should be further examined.

Characteristics of the study population
 Patients on PD (n=10)Controls (n=41)P value^
Age (years)55 [48.8, 61.5]51 [45, 59]0.55
Male3 (30)23 (56.1)0.14
African American4 (40)23 (56.1)0.25
Caucasian5 (50)18 (43.9)
BMI (kg/m^2)23.6 [21.9, 17.9]27.6 [25.4, 31.4]0.07
Creatinine (mg/dL)10.3 [7.2, 13.3]0.9 [0.8, 1.1]<0.001
Urine output (mL/day)100 [50, 520]  

Continuous variables are presented as median [interquartile range], categorical variables are presented as n (%).

Funding

  • Commercial Support