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Abstract: FR-PO688

Tissue Sodium Stores in Peritoneal Dialysis Patients

Session Information

Category: Dialysis

  • 703 Dialysis: Peritoneal Dialysis


  • Tintara, Supisara, Vanderbilt University School of Medicine, Nashville, Tennessee, United States
  • Alsouqi, Aseel, Vanderbilt University Medical Center, Nashville, Tennessee, United States
  • Deger, Serpil muge, Vanderbilt University Faculty of Medicine Department of Nephrology, Nashville, Tennessee, United States
  • Bian, Aihua, Vanderbilt University, Nashville, Tennessee, United States
  • Stewart, Thomas G., Vanderbilt University Medical Center, Nashville, Tennessee, United States
  • Titze, Jens, Duke - National University of Singapore, Singapore, Singapore
  • Ikizler, Talat Alp, Vanderbilt University Medical Center, Nashville, Tennessee, United States

A remarkable amount of sodium (Na+) is stored in the tissue without commensurate water retention, particularly in the skin and muscle. Using 23Na-magnetic resonance imaging (MRI), elevated tissue Na+ content was found in hemodialysis patients. Peritoneal dialysis (PD) patients generally have higher residual kidney function than HD patients, yet the effectiveness of PD in tissue Na+ removal has not been evaluated.


We examined tissue Na+ levels in 10 PD patients. PD patients were matched with healthy controls by age, race, gender and body mass index (BMI). All study subjects underwent 23Na-MRI to quantify Na+ levels in lower leg muscle and skin.


We studied 10 PD patients and 41 controls. PD patients had significantly higher skin and muscle Na+ levels compared to controls (figure 1). In PD subjects, skin Na+ level was inversely correlated to ultrafiltration volume, a marker of Na+ removal adequacy (figure 2).


Our data suggest that PD patients have elevated tissue Na+ stores. The mechanisms by which this abnormality develops and its consequences should be further examined.

Characteristics of the study population
 Patients on PD (n=10)Controls (n=41)P value^
Age (years)55 [48.8, 61.5]51 [45, 59]0.55
Male3 (30)23 (56.1)0.14
African American4 (40)23 (56.1)0.25
Caucasian5 (50)18 (43.9)
BMI (kg/m^2)23.6 [21.9, 17.9]27.6 [25.4, 31.4]0.07
Creatinine (mg/dL)10.3 [7.2, 13.3]0.9 [0.8, 1.1]<0.001
Urine output (mL/day)100 [50, 520]  

Continuous variables are presented as median [interquartile range], categorical variables are presented as n (%).


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