Kidney Week

Abstract: FR-PO560

The Impact of Onset Age on Metabolic Disorders in Urolithiasis

Session Information

• Physical Activity, Body Composition, Metabolism: Clinical
  October 26, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Health Maintenance, Nutrition, and Metabolism

• 1302 Health Maintenance, Nutrition, and Metabolism: Clinical

Authors

• Wen, Wen, Beijing Tsinghua Changgung Hospital, Medical center, Tsinghua University, Beijing, BeiJIng, China

Wen Wen,

• Li, Yuehong, Beijing Tsinghua Changgung Hospital, Medical center, Tsinghua University, Beijing, BeiJIng, China

Yuehong Li,

• Chen, Qi, Beijing Tsinghua Changgung Hospital, Medical center, Tsinghua University, Beijing, BeiJIng, China

Qi Chen,

Background

Urolithiasis is related with metabolic disease, such as hyperuricemia, diabetes, dyslipidemia and hypertension. We aim to explore the association between the metabolic diseases and the stone type, clinical and laboratory features, the onset age with urolithiasis patients.

Methods

Clinical data were retrospectively collected from 707 patients with urolithiasis surgery in Beijing Tsinghua Changgung Hospital from December 2015 to August 2017. Their demographic data, clinical manifestations, laboratory tests and examinations were analyzed retrospectively.

Results

(1) 446 males and 261 females (18 to 94 years old) from 28 provinces in China were included in our study. The urolithiasis patients with onset age > 30 years old are more likely common to diabetes mellitus, hypertension, gout, hyperlipidemia and metabolic syndrome. (2) The onset age of urolithiasis is positively associated with BMI (r=0.100, P=0.011), iPTH (r=0.089, P=0.049), TG (r=0.083, P=0.033), globulin (r=0.077, P=0.046) and IgG (r=0.077, P= 0.040), while it is negatively related to urine phosphorous (r=-0.109, P=0.027) and HDL-C (r=-0.099, P=0.010). (3) Correlation analysis showed that the level of TC and LDL-C were both positively associated with serum calcium, phosphorus, alkaline phosphatase (ALP), globulin and white blood cell (WBC) (P<0.05). The level of TG is positively associated with serum calcium, magnesium, 25-OH-VitD₃, while negatively associated with urine PH (P<0.05). HDL-C was negatively associated with urine uric acid (P<0.05). Fast glucose was positively associated with serum ALP, globulin and the count of urine bacterium (P<0.05). Serum uric acid was positively associated with serum calcium, phosphorous and urine phosphorus (P<0.05). (4) The incidence of urinary infection (70.3% vs. 62.2%, P=0.025) and amorphous calcium phosphate (1% vs. 0%, P=0.043) is significantly higher in patients with hyperlipidemia.

Conclusion

The urolithiasis patients with onset age > 30 years old are more likely associated with metabolic disorders and urinary infections. Elevation of serum lipid, glucose and urate acid may add risks to urolithiasis by impacting urine PH, calcium-phosphorus metabolism and infectious status.

Funding

• Private Foundation Support