Abstract: FR-PO161
The Presence of Simple Renal Cyst Is Associated with Increased Risk of Albuminuria in Young Adults
Session Information
- CKD: Epidemiology, Risk Factors, Prevention - II
October 26, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 1901 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Boo, Hyo jin, Samsung medical center, Seoul, Korea (the Republic of)
- Baeg, Song in, Samsung Medical Center, Seoul, Korea (the Republic of)
- Kim, Minjung, Samsung medical center, Seoul, Korea (the Republic of)
- Lee, Eun jeong, Samsung Medical Center, Seoul, Korea (the Republic of)
- Huh, Wooseong, Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of)
- Kim, Dae Joong, Samsung medical center Sungkyunkwan University School of medicine, Seoul, Korea (the Republic of)
- Kim, Yoon-Goo, Samsung Medical Center, Seoul, Korea (the Republic of)
- Oh, Ha Young, Samsung medical center Sungkyunkwan University School of medicine, Seoul, Korea (the Republic of)
- Lee, Jung eun, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of)
Background
It is well-known that the prevalence of simple renal cyst increases with age. However, simple cysts are occasionally found in adults younger than 40 years of age. This cross-sectional study evaluated the clinical significance of simple renal cysts in young adults, focusing on the associations with hypertension and albuminuria.
Methods
Adults younger than 40 years who received comprehensive medical checkup from January 2005 to December 2013 were included. Simple renal cysts were identified by ultrasonography.
Results
Among 5832 young adults, renal cysts were found in 276 subjects (4.7%). Subjects diagnosed with polycystic kidney disease (n=5) or medullary sponge kidney (n=1) were excluded from the analyses. A single cyst and multiple cysts were found in 234 (4.0%) and 42 (0.7%) subjects, respectively. The locations of single cyst were cortex in 187, medulla in 26, and parapelvic region in 21. In univariate logistic regression analyses, age, male sex, body mass index, waist circumference, systolic blood pressure (SBP), hypertension, current smoking, high-density lipoprotein cholesterol, and uric acid levels were associated with a higher prevalence of simple cysts. Multivariate analyses of cysts showed that age (OR, 1.07; CI, 1.02-1.12), SBP (OR, 1.01; CI, 1.00-1.02), and hypertension (OR, 1.85; CI, 1.24-2.76) had independent associations with the presence of simple cysts. The subjects with cysts had a higher prevalence of albuminuria (defined as a urine albumin to creatinine ratio > 30μg/mg) than those without cysts (11.2% vs. 4.5%, P <0.001). Multivariate analyses of albuminuria revealed that the presence of simple renal cysts was associated with a 2.32-fold increase in the risk of albuminuria (95% CI, P <0.001). The location of the cysts was not related to the prevalence of albuminuria.
Conclusion
Age, SBP, and hypertension history were independently associated with simple renal cyst in adults younger than 40. The presence of the renal cyst was an independent risk factor of albuminuria.