Kidney Week

Abstract: FR-PO161

The Presence of Simple Renal Cyst Is Associated with Increased Risk of Albuminuria in Young Adults

Session Information

• CKD: Epidemiology, Risk Factors, Prevention - II
  October 26, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: CKD (Non-Dialysis)

• 1901 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

• Boo, Hyo jin, Samsung medical center, Seoul, Korea (the Republic of)

Hyo jin Boo,

• Baeg, Song in, Samsung Medical Center, Seoul, Korea (the Republic of)

Song in Baeg,

• Kim, Minjung, Samsung medical center, Seoul, Korea (the Republic of)

Minjung Kim,

• Lee, Eun jeong, Samsung Medical Center, Seoul, Korea (the Republic of)

Eun jeong Lee,

• Huh, Wooseong, Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of)

Wooseong Huh,

• Kim, Dae Joong, Samsung medical center Sungkyunkwan University School of medicine, Seoul, Korea (the Republic of)

Dae Joong Kim,

• Kim, Yoon-Goo, Samsung Medical Center, Seoul, Korea (the Republic of)

Yoon-Goo Kim,

• Oh, Ha Young, Samsung medical center Sungkyunkwan University School of medicine, Seoul, Korea (the Republic of)

Ha Young Oh,

• Lee, Jung eun, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Republic of)

Jung eun Lee,

Background

It is well-known that the prevalence of simple renal cyst increases with age. However, simple cysts are occasionally found in adults younger than 40 years of age. This cross-sectional study evaluated the clinical significance of simple renal cysts in young adults, focusing on the associations with hypertension and albuminuria.

Methods

Adults younger than 40 years who received comprehensive medical checkup from January 2005 to December 2013 were included. Simple renal cysts were identified by ultrasonography.

Results

Among 5832 young adults, renal cysts were found in 276 subjects (4.7%). Subjects diagnosed with polycystic kidney disease (n=5) or medullary sponge kidney (n=1) were excluded from the analyses. A single cyst and multiple cysts were found in 234 (4.0%) and 42 (0.7%) subjects, respectively. The locations of single cyst were cortex in 187, medulla in 26, and parapelvic region in 21. In univariate logistic regression analyses, age, male sex, body mass index, waist circumference, systolic blood pressure (SBP), hypertension, current smoking, high-density lipoprotein cholesterol, and uric acid levels were associated with a higher prevalence of simple cysts. Multivariate analyses of cysts showed that age (OR, 1.07; CI, 1.02-1.12), SBP (OR, 1.01; CI, 1.00-1.02), and hypertension (OR, 1.85; CI, 1.24-2.76) had independent associations with the presence of simple cysts. The subjects with cysts had a higher prevalence of albuminuria (defined as a urine albumin to creatinine ratio > 30μg/mg) than those without cysts (11.2% vs. 4.5%, P <0.001). Multivariate analyses of albuminuria revealed that the presence of simple renal cysts was associated with a 2.32-fold increase in the risk of albuminuria (95% CI, P <0.001). The location of the cysts was not related to the prevalence of albuminuria.

Conclusion

Age, SBP, and hypertension history were independently associated with simple renal cyst in adults younger than 40. The presence of the renal cyst was an independent risk factor of albuminuria.