Abstract: FR-PO670
A Time-Varying Analysis: The Relationship Between Serum Uric Acid and Residual Renal Function Loss in CAPD Patients
Session Information
- Dialysis: Peritoneal Dialysis - II
October 26, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 703 Dialysis: Peritoneal Dialysis
Author
- Lun, Yang Chieh, zhong-shan university, Guangzhou, China
Background
Residual renal function(RRF) is significantly associated with mortality and quality of life in peritoneal dialysis(PD) patients. A number of studies demonstrated that pre-dialysis serum uric acid(UA) was predictor of RRF loss in PD patients. However, the relationship between serum uric acid and RRF loss in patients over time are unknown.
Methods
This is a single-center, retroperspective cohort study. Total 201 CAPD patients who started PD between January1, 2008 and April 30, 2016 at the third affiliated hospital of Sun-Yat Sun University were eligible for the study with follow-up through December 31, 2016. Urine volume, biochemical and therapeutic information was collected within 1 month of PD commencement and at every 3-month intervals thereafter. Cox proportional hazard regression models and penalized splines analysis were employed to analyze the association between uric acid and RRF loss and to identify independent risk factors of RRF loss.
Results
During the period of first five years in PD, 86 patients became anuria. Multivariate Cox regression analysis showed that uric acid, 5-year peritonitis rate, ultrafiltration and phosphorous were independent risk factors of RRF loss while KT/V urea was a protective factor. Using Cox proportional hazard regression models and penalized splines analysis, when compared to patients with UA 403-455umol/L, patients with UA>455umol/L (HR=1.99, 95%CI 1.021-3.345; p<0.05) or UA<403umol/L (HR=2.12, 95%CI 1.005-3.611; p<0.05), UA levels conferred a higher risk of RRF loss, while it showed a U-shaped relationship between continuous UA levels and RRF loss.
Conclusion
A U-shaped relationship between UA levels and RRF loss was found in patients over time. Uric acid, 5-year peritonitis rate, ultrafiltration, phosphorous, and KT/V urea were independent risk factors for RRF loss in CAPD patients.