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Kidney Week

Abstract: SA-PO709

Association Between eGFR and Cognitive Performance

Session Information

  • Geriatric Nephrology
    October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Geriatric Nephrology

  • 1100 Geriatric Nephrology

Authors

  • Genest, Suzanne Dominique, Université de Montréal, Montreal, Quebec, Canada
  • Goupil, Remi, Hopital du Sacre-Coeur de Montreal, Montreal, Quebec, Canada
  • Bouchard, Josee, Hopital du Sacre-Coeur de Montreal, Montreal, Quebec, Canada
  • Troyanov, Stephan, Hopital du Sacre-Coeur de Montreal, Montreal, Quebec, Canada
  • Madore, Francois, Hopital du Sacre-Coeur de Montreal, Montreal, Quebec, Canada
Background

Moderate to severe chronic renal failure is known to be associated with cognitive impairment; however, few studies have looked at the impact of subclinical kidney dysfunction on cognition. This study aimed at investigating the association between cognition and eGFR in a population-based cohort.

Methods

We evaluated cardiovascular, renal and cognitive profiles in randomly selected individuals from the general population between the ages of 40 and 69 years. Cognitive function was quantified by computer-based testing of reaction time, paired associates learning (memory), and verbal-numerical reasoning. eGFR was estimated using the CKD-EPI equation. We used multivariate analysis to study the association between eGFR and cognition, while adjusting for confounders, including age, gender, income, education, smoking, hypertension, dyslipidemia, diabetes, body mass index, cardiovascular diseases, alcohol intake and psychoactive medication use.

Results

A total of 15 897 patients had cognitive testing and eGFR measurements performed during the same clinic visit. Mean eGFR was 88.0± 14.6 ml/min/1.73m2. After adjusting for age, gender, income, education, alcohol intake and known cardiovascular risk factors, lower eGFR was significantly associated with poorer performance on reaction time testing, paired associates learning (memory), and verbal-numerical reasoning. These associations remained significant after further adjustment for use of psychoactive medications (cf. table).

Conclusion

Subclinical renal dysfunction may be associated with impaired cognitive performance, independently of known risk factors for cognitive decline.

Funding

  • Government Support - Non-U.S.