Kidney Week

Abstract: SA-PO554

Continuous Renal Replacement Therapy Is Associated with Acute Myocardial Injury in Critically Ill Patients

Session Information

• AKI: Clinical, Outcomes, Trials - II
  October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Acute Kidney Injury

• 102 AKI: Clinical, Outcomes, and Trials

Authors

• Slessarev, Marat, University of Western Ontario, London, Ontario, Canada

Marat Slessarev,

• Salerno, Fabio R., Clinica Nefrologica H San Gerardo, Monza, Italy

Fabio R. Salerno,

• McIntyre, Christopher W., London Health Sciences Centre, London, Ontario, Canada

Christopher W. McIntyre,

Background

Intermittent renal replacement therapy induces cardiac stunning in chronic hemodialysis (HD) and acute kidney injury (AKI) patients. In chronic HD, recurrent stunning contributes to heart failure and cardiac death, with ultrafiltration and intra-dialytic hypotension being the principal determinants of this injury. Continuous renal replacement therapy (CRRT), with its lower ultrafiltration rates and improved hemodynamic profile, should protect against cardiac stunning in AKI. We assessed whether CRRT is associated with cardiac stunning in critically ill patients with AKI.

Methods

We prospectively measured cardiac function using global and segmental longitudinal left ventricular (LV) strain derived from transthoracic echocardiography in 11 critically ill patients who were started on CRRT for AKI. We compared measurements at 4, 8 and 24 hours to baseline immediately prior to initiation of CRRT, with each patient serving as their own control. We also recorded blood pressure, heart rate, dose of vasoactive medications and ICU mortality.

Results

10/11 patients developed new regional cardiac stunning, with 8/11 within 4 hours of starting CRRT, despite stable hemodynamics. The number of affected LV segments varied from 1 to 11 (out of 12). The stunning occurred both in patients with preserved and impaired baseline cardiac function, and 7/11 patients died in the ICU.

Conclusion

Initiation of CRRT in critically ill patients with AKI is associated with cardiac stunning despite stable hemodynamics. This mechanism may explain lack of clinical benefit of CRRT over intermittent modalities and warrants further investigation to improve cardiovascular outcomes in critically ill patients with AKI.