Kidney Week

Abstract: TH-PO178

The Efficacy of Exercise Training in Kidney Transplant Recipients: A Systematic Review and Meta-Analysis

Session Information

• Transplantation: Cardiovascular and Metabolic Diseases
  October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Transplantation

• 1802 Transplantation: Clinical

Authors

• Oguchi, Hideyo, Department of Nephrology, Toho University Faculty of Medicine, Tokyo, Japan

Hideyo Oguchi,

• Tsujita, Makoto, Nagoya Daini Red Cross Hospital, Nagoya, Japan

Makoto Tsujita,

• Yazawa, Masahiko, Division of Nephrology and Hypertension, Department of Internal Medicine, St.Marianna University School of Medicine, Kawasaki, Japan

Masahiko Yazawa,

• Kawaguchi, Takehiko, National Hospital Organization Chiba-East Hospital, Chiba, Japan

Takehiko Kawaguchi,

• Hoshino, Junichi, Toranomon Hospital, Tokyo, Japan

Junichi Hoshino,

• Kohzuki, Masahiro, Tohoku University Graduate School of Medicine, Sendai, Japan

Masahiro Kohzuki,

• Ito, Osamu, Tohoku Medical Pharmacetical University Faculty of Medicine, Sendai, MIyagi, Japan

Osamu Ito,

• Yamagata, Kunihiro, University of Tsukuba, Tsukuba, Japan

Kunihiro Yamagata,

• Shibagaki, Yugo, St Marianna University Hospital, Kawasaki, Japan

Yugo Shibagaki,

• Sofue, Tadashi, Kagawa University, Kita-gun, KAGAWA , Japan

Tadashi Sofue,

Background

The effectiveness of exercise in kidney transplant recipients is not well established. We therefore performed a systematic review of the effects of exercise training in kidney transplantation recipients.

Methods

We searched two electronic databases for articles up to April 2017. Inclusion criteria were as follows: randomized controlled trial and kidney transplant recipients aged 18 years or older. The main outcomes were allograft function (estimated glomerular filtration rate, eGFR), exercise tolerance (VO2 peak), and quality of life (QOL).

Results

After screening of 1,303 references in PubMed and Ichushi, six randomized control trials were analyzed. For kidney transplant recipients, supervised exercise training was shown to significantly improve VO2 peak (mean difference, 2.42; 95% confidence interval (95%CI) 0.22–4.63) and QOL (mean difference, 7.23; 95%CI 0.94–13.52). However, exercise training did not improve allograft kidney function (mean difference, 6.22; 95%CI -13.00–25.44). No reporting bias was observed in any of the outcomes.

Conclusion

Exercise training for kidney transplant recipients significantly improved exercise tolerability and QOL, but a significant improvement was not obtained with respect to allograft kidney function.